About   Help   FAQ
Transgenic Allele Detail
Symbol: Col1a1Mov13
Name: collagen, type I, alpha 1; Moloney leukemia virus 13
MGI ID: MGI:1856671
Gene: Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Strain of Origin:  C57BL/6
Transgene Type:    Transgenic
Mutation:    Viral insertion
Mutation detailsExperimental integration of a proviral genome occurred in the first intron 19 base pairs downstream of the intron/exon boundary, and leads to complete transcriptional block in most cell types, except for odontoblasts and some osteoblasts. (J:7142, J:7398)
Inheritance:    Dominant
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:  143 strains or lines available
A yeast artificial chromosome (YAC) 150 kb long that spans the Col1a1 gene has been introduced into fibroblasts carrying the Col1a1Mov13 mutation. The YAC complements the mutant gene, conferring normal collagen RNA expression (J:722). It can also be introduced transgenically into the germ line (J:4495).
Original:  J:6514 Jaenisch R, et al., Chromosomal position and activation of retroviral genomes inserted into the germ line of mice. Cell. 1981 May;24(2):519-29
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.20
The Jackson Laboratory