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Soat1ald
Spontaneous Allele Detail
Nomenclature
Symbol: Soat1ald
Name: sterol O-acyltransferase 1; adrenocortical lipid depletion
MGI ID: MGI:1856648
Synonyms: Acact-, ald, hid, Soat1hid
Gene: Soat1  Location: Chr1:156428108-156474328 bp, - strand  Genetic Position: Chr1, 67.71 cM
Mutation
origin
Strain of Origin:  AKR/O
Mutation
description
Allele Type:    Spontaneous
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsDeletion of 118 bp in the a Soat1 mRNA. This region corresondes to the 5'UTR and the initial coding sequences. In addition, two missense mutations were observed: A1248G resulting in Ile to Val at amino acid 147 and C1422T resulting in His to Tyr at amino acid 205. Other nucleotide differences were observed that did not result in amino acid changes. A truncated protein is expressed from this allele, presumably due to internal initiation. (J:42073, J:180857)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Soat1 Mutation:  10 strains or lines available
Notes
All AKR sublines are homozygous for Soat1.
References
Original:  J:12157 Arnesen K, The cytology of the adrenal cortex in mice with spontaneous adrenocortical lipid depletion. Acta Pathol Microbiol Scand. 1963;58:212-218
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory