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Pgap1oto
Radiation induced Allele Detail
Summary
Symbol: Pgap1oto
Name: post-GPI attachment to proteins 1; otocephaly
MGI ID: MGI:1856621
Synonyms: otoxray
Gene: Pgap1  Location: Chr1:54512159-54596843 bp, - strand  Genetic Position: Chr1, 27.25 cM
Alliance: Pgap1oto page
Forebrain defects in Pgap1oto/Pgap1oto, Pgap1oto/Pgap1tm1Asp, and Pgap1tm1Asp/Pgap1tm1Asp embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  STOCK In(1)1Rk/J
Mutation
description
Allele Type:    Radiation induced
Mutation:    Undefined
 
Mutation detailsWhile no mutations could be identified in cDNA sequence, northern blot analysis confirmed reduced expression of Pgap1 protein in adult mutant tissue and E10.5 embryos. mRNA length is normal indicating the mutational event disrupts a regulatory region, attenuating transcription. (J:151594)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 41 assay results
In Structures Affected by this Mutation: 27 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pgap1 Mutation:  53 strains or lines available
Notes
This mutation was probably induced by X irradiation of a male homozygous for the Chr 1 inversion In(1)1Rk. Segregation among descendants of this male showed that oto is either within or closely linked to the inversion.
References
Original:  J:7938 Juriloff DM, et al., Genetic and developmental studies of a new mouse mutation that produces otocephaly. J Craniofac Genet Dev Biol. 1985;5(2):121-45
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory