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Sobpjc
Spontaneous Allele Detail
Nomenclature
Symbol: Sobpjc
Name: sine oculis binding protein; Jackson circler
MGI ID: MGI:1856614
Gene: Sobp  Location: Chr10:42878496-43050526 bp, - strand  Genetic Position: Chr10, 22.89 cM
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsA 10 bp deletion is found in exon 6 eliminating nucleotides 1346-1355 of the BC059851 coding sequence. This results in the deletion of 48% of the protein. (J:137716)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sobp Mutation:  25 strains or lines available
Notes
Homozygotes show erratic circling behavior which becomes more pronounced with age. They can swim. They are very active, bobbing up and down and flexing head and trunk ventrally towards the tail. Flexing behavior when suspended by tail is diagnostic at weaning age. jc is not allelic with other circling mutants on Chr 10 (J:13506).
References
Original:  J:13506 Southard JL, Jackson circler, jc. Mouse News Lett. 1970;42:30
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory