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Radiation induced Allele Detail
Symbol: MipHfi
Name: major intrinsic protein of lens fiber; hydropic fibers
MGI ID: MGI:1856608
Synonyms: 538
Gene: Mip  Location: Chr10:128225838-128231812 bp, + strand  Genetic Position: Chr10, 76.49 cM, cytoband D1
Strain of Origin:  (101 x C3H)F1
Allele Type:    Radiation induced
Mutation:    Intragenic deletion
Mutation detailsA 76 bp deletion that removes 17 bp from the 3' end of exon 2 and 59 bp of intron 2. In the encoded mRNA, 165 bp of coding sequence is removed resulting from exon 2 being skipped during the splicing process. By immunoblot analysis on lens cell memebrane preparations, a smaller mutant protein was detected in homozygous mutant mice, although at lower levels that the wild-type protein. (J:70225)
Inheritance:    Semidominant
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mip Mutation:  24 strains or lines available
Original:  J:14285 Kratochvilova J, Allelism tests of 15 autosomal cataract mutations. Mouse Genome. 1990;86:249-50
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory