Lpin1^fld
Spontaneous Allele Detail

Summary

• Symbol: Lpin1^fld
• Name: lipin 1; fatty liver dystrophy
• MGI ID: MGI:1856603
• Synonyms: fld
• Gene: Lpin1 Location: Chr12:16585670-16696967 bp, - strand Genetic Position: Chr12, 7.9 cM
• Alliance: Lpin1^fld page

Lpin1^fld/Lpin1^fld and control

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: BALB/cByJ

Mutation description

• Allele Type: Spontaneous
• Mutations: Insertion, Intragenic deletion, Inversion
• Lpin1^fld involves 1 genes/genome features (Lpin1) View all
• Mutation details: Three molecular changes have been identified in this allele. A 2 kb deletion encompasses exons 2 and 3 including the translation initiation sequence. An inversion exceeding 40 kb encompasses much of the coding region. An additional 0.5 kb sequence downstream of the inverted 40 kb has been duplicated and inserted in reverse orientation just upstream of this 40 kb inversion. Northern blots of adipose tissue extracts failed to detect mRNA from mice homozygous for this allele. (J:66739)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lpin1 Mutation: 56 strains or lines available

References

• Original: J:64452 Sweet HO, et al., fld - fatty liver dystrophy. Mouse News Lett. 1988;81:69
• All: 35 reference(s)