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Radiation induced Allele Detail
Symbol: Tyrc-14CoS
Name: tyrosinase; albino deletion 14CoS, Oak Ridge
MGI ID: MGI:1856580
Synonyms: c14CoS, cA1, Fah-
Gene: Tyr  Location: Chr7:87424771-87493512 bp, - strand  Genetic Position: Chr7, 49.01 cM
Strain of Origin:  (101 x C3H)F1
Allele Type:    Radiation induced
Mutation:    Intergenic deletion
    Large intergenic deletion. (J:5435)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
In Mice Carrying this Mutation: 11 assay results
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tyr Mutation:  366 strains or lines available
Tyrc-14CoS. This induced mutation was found at Oak Ridge National Laboratory. Homozygotes die neonatally (J:5063), and have deficiencies in activity of at least five liver enzymes, glucose-6-phosphatase, tyrosine aminotransferase, serine dehydratase, glutamine synthetase, and UDP-glucuronyltransferase, as well as low levels of liver microsomal cytochrome P-450 and the plasma proteins, albumin, a-fetoprotein, and transferrin (J:5715, J:5588, J:5730). Control of the level of two enzymes occurs at the transcriptional level; control of the level of the three plasma proteins occurs posttranscriptionally (J:7838, J:7840). There is a marked decrease in the number of receptors for insulin and glucocorticoids (J:6996) and for epidermal growth factor and glucagon (J:12047). Two specific liver polypeptides recognizable in two-dimensional gels are lacking (J:7420). The rough endoplasmic reticulum of the liver, and to a lesser extent of the kidneys, is dilated and vesiculated (J:5386). Complementation studies with other alleles have shown that this is probably the shortest of the six deletions (J:5435). It is known not to include the Mod2 locus (J:5437).

Compound heterozygotes carrying Tyrc-ch show dilution of the chinchilla pigmentation compared to homozygous chinchilla mice (Tyrc-ch/Tyrc-ch, J:5435).

Original:  J:5063 Erickson RP, et al., Glucose-6-phosphatase deficiency caused by radiation-induced alleles at the albino locus in the mouse. Proc Natl Acad Sci U S A. 1968 Feb;59(2):437-44
All:  27 reference(s)

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