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Tgfatm1Ard
Targeted Allele Detail
Nomenclature
Symbol: Tgfatm1Ard
Name: transforming growth factor alpha; targeted mutation 1, Ashley R Dunn
MGI ID: MGI:1856577
Synonyms: Tgfalpha -
Gene: Tgfa  Location: Chr6:86195223-86275719 bp, + strand  Genetic Position: Chr6, 37.62 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:4606
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A neomycin cassette was inserted into exon 3 of the gene. (J:4606)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 12 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tgfa Mutation:  15 strains or lines available
Notes
In conjunction with Fgf7tm1Efu, double homozygous mutant mice display no additional abnormalities nor increase in severity of phenotypes over individual homozygous mutants. (J:31155)
References
Original:  J:4606 Mann GB, et al., Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. Cell. 1993 Apr 23;73(2):249-61
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory