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Ghrhrlit
Spontaneous Allele Detail
Nomenclature
Symbol: Ghrhrlit
Name: growth hormone releasing hormone receptor; little
MGI ID: MGI:1856425
Synonyms: lit, litm
Gene: Ghrhr  Location: Chr6:55376295-55388530 bp, + strand  Genetic Position: Chr6, 27.38 cM
Ghrhrlit/Ghrhrlit and Ghrhrlit/Ghrhr+ mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsThe mutation in little mice is a A-to-G transition in codon 60 that alters this residue from a aspartate to a glycine in the encoded protein (p.D60G). Reduced levels of mRNA were noted in total RNA derived from pituitary of homozygous mice, and in vitro assays demonstrated that no functional protein is made from this allele. (J:12846, J:13404)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ghrhr Mutation:  23 strains or lines available
References
Original:  J:64445 Eicher EM, lit - little. Mouse News Lett. 1972;47:36
All:  64 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory