Ghrhr^lit
Spontaneous Allele Detail

Summary

• Symbol: Ghrhr^lit
• Name: growth hormone releasing hormone receptor; little
• MGI ID: MGI:1856425
• Synonyms: lit, lit^m
• Gene: Ghrhr Location: Chr6:55353280-55365515 bp, + strand Genetic Position: Chr6, 27.38 cM
• Alliance: Ghrhr^lit page

Ghrhr^lit/Ghrhr^lit and Ghrhr^lit/Ghrhr⁺ mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: The mutation in little mice is a A-to-G transition in codon 60 that alters this residue from a aspartate to a glycine in the encoded protein (p.D60G). Reduced levels of mRNA were noted in total RNA derived from pituitary of homozygous mice, and in vitro assays demonstrated that no functional protein is made from this allele. (J:12846, J:13404)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Ghrhr Mutation: 32 strains or lines available

References

• Original: J:64445 Eicher EM, lit - little. Mouse News Lett. 1972;47:36
• All: 70 reference(s)