Gnrh1^hpg
Spontaneous Allele Detail

Summary

• Symbol: Gnrh1^hpg
• Name: gonadotropin releasing hormone 1; hypogonadal
• MGI ID: MGI:1856393
• Synonyms: Gnrh^-, gnrh^hpg, hpg
• Gene: Gnrh1 Location: Chr14:67982717-67986889 bp, + strand Genetic Position: Chr14, 34.66 cM
• Alliance: Gnrh1^hpg page

Characterization of Gnrh1^hpg/Gnrh1^hpg mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C3H101H-Rb(1.3)1Bnr

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: The mutation in the hypogonadal mouse is an approximately 33.5 kb deletion that removes two exons that encode most of the protein. (J:8515, J:14505, J:94662)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	46 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Gnrh1^hpg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gnrh1 Mutation: 10 strains or lines available

References

• Original: J:5877 Cattanach BM, et al., Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism. Nature. 1977 Sep 22;269(5626):338-40
• All: 96 reference(s)