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Gnrh1hpg
Spontaneous Allele Detail
Nomenclature
Symbol: Gnrh1hpg
Name: gonadotropin releasing hormone 1; hypogonadal
MGI ID: MGI:1856393
Synonyms: Gnrh-, gnrhhpg, hpg
Gene: Gnrh1  Location: Chr14:67745181-67749439 bp, + strand  Genetic Position: Chr14, 34.66 cM
Characterization of Gnrh1hpg/Gnrh1hpg mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C3H101H-Rb(1.3)1Bnr
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsThe mutation in the hypogonadal mouse is an approximately 33.5 kb deletion that removes two exons that encode most of the protein. (J:8515, J:14505, J:94662)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 43 assay results
In Structures Affected by this Mutation: 18 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gnrh1 Mutation:  5 strains or lines available
References
Original:  J:5877 Cattanach BM, et al., Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism. Nature. 1977 Sep 22;269(5626):338-40
All:  93 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory