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Gnrh1hpg
Spontaneous Allele Detail
Summary
Symbol: Gnrh1hpg
Name: gonadotropin releasing hormone 1; hypogonadal
MGI ID: MGI:1856393
Synonyms: Gnrh-, gnrhhpg, hpg
Gene: Gnrh1  Location: Chr14:67982630-67986885 bp, + strand  Genetic Position: Chr14, 34.66 cM
Alliance: Gnrh1hpg page
Characterization of Gnrh1hpg/Gnrh1hpg mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C3H101H-Rb(1.3)1Bnr
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsThe mutation in the hypogonadal mouse is an approximately 33.5 kb deletion that removes two exons that encode most of the protein. (J:8515, J:14505, J:94662)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 46 assay results
In Structures Affected by this Mutation: 15 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Gnrh1hpg
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gnrh1 Mutation:  8 strains or lines available
References
Original:  J:5877 Cattanach BM, et al., Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism. Nature. 1977 Sep 22;269(5626):338-40
All:  96 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory