About   Help   FAQ
Plp1jp-4J
Spontaneous Allele Detail
Nomenclature
Symbol: Plp1jp-4J
Name: proteolipid protein (myelin) 1; jimpy 4 Jackson
MGI ID: MGI:1856375
Gene: Plp1  Location: ChrX:135723420-135740482 bp, + strand  Genetic Position: ChrX, 59.1 cM, cytoband F1-F2
Mutation
origin
Strain of Origin:  C3H/HeJ
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsSequencing of Plp genomic and cDNAs showed a single nucleotide substitution, G-to-T, in exon 2 at coding nucleotide 115 which causes an alanine to serine substitution at position39 (p.Ala39Ser). Northern analysis showed that PLP mRNA was reduced by 90% in Plpjp-4J/Y compared to +/Y wild-type mice. (J:41569)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plp1 Mutation:  19 strains or lines available
References
Original:  J:30778 Sweet HO, et al., Remutations at The Jackson Laboratory (Update to Mouse Genome 1993; 91:862-5 - J16313). Mouse Genome. 1995;93(4):1030-4
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2022
MGI 6.20
The Jackson Laboratory