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Radiation induced Allele Detail
Symbol: Tyrc-65K
Name: tyrosinase; albino 65 Oak Ridge
MGI ID: MGI:1856309
Synonyms: c65K, cE1
Gene: Tyr  Location: Chr7:87424771-87493512 bp, - strand  Genetic Position: Chr7, 49.01 cM
Strain of Origin:  Not Specified
Allele Type:    Radiation induced
Mutation:    Undefined
Mutation detailsTyrc-65K and Tyrc-112K are derived from the same male in matings sampling X-irradiated spermatogonial stem cells. They are presumed to have resulted from a single mutational event. (J:23420)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tyr Mutation:  366 strains or lines available

The c65K mutation is identical to the c112K mutation and both are presumed to have resulted from a single mutational event. The two lines of mice carrying these mutations were derived from the same mutagenized male (J:23420).

The phenotype of mice carrying this allele is similar to Tyrc-3H in most respects studied, including neonatal death, effect on liver enzymes and serum proteins (J:5435), and defective rough endoplasmic reticulum of liver (J:5386).

Compound heterozygotes carrying Tyrc-ch show dilution of the chinchilla pigmentation compared to homozygous chinchilla mice (Tyrc-ch/Tyrc-ch, J:5435). Compound heterozygotes with Tyrc-6H are infertile (J:5435).

Original:  J:5435 Gluecksohn-Waelsch S, et al., Complementation studies of lethal alleles in the mouse causing deficiencies of glucose-6-phosphatase, tyrosine aminotransferase, and serine dehydratase. Proc Natl Acad Sci U S A. 1974 Mar;71(3):825-9
All:  4 reference(s)

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MGI 6.03
The Jackson Laboratory