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Tyrc-112K
Radiation induced Allele Detail
Nomenclature
Symbol: Tyrc-112K
Name: tyrosinase; albino 112, Oak ridge
MGI ID: MGI:1856308
Synonyms: 112K, c112K, cE, cE1'
Gene: Tyr  Location: Chr7:87427405-87493411 bp, - strand  Genetic Position: Chr7, 49.01 cM
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Radiation induced
Mutation:    Intergenic deletion
 
Mutation details
Inheritance:    Recessive
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tyr Mutation:  274 strains or lines available
Notes
The phenotype of mice carrying this allele is similar to Tyrc-3H in most respects studied, including neonatal death, effect on liver enzymes and serum proteins (J:5435), and defective rough endoplasmic reticulum of liver (J:5386).

Compound heterozygotes carrying Tyrc-ch show dilution of the chinchilla pigmentation compared to homozygous chinchilla mice (Tyrc-ch/Tyrc-ch, J:5435). Compound heterozygotes with Tyrc-6H show reproductive activity however embryos died at about 8 days gestation (J;5435).

References
Original:  J:5435 Gluecksohn-Waelsch S, et al., Complementation studies of lethal alleles in the mouse causing deficiencies of glucose-6-phosphatase, tyrosine aminotransferase, and serine dehydratase. Proc Natl Acad Sci U S A. 1974 Mar;71(3):825-9
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory