About   Help   FAQ
Radiation induced Allele Detail
Symbol: Del(7)Tyrc-3H
Name: deletion, Chr 7, albino 3 Harwell
MGI ID: MGI:1856304
Synonyms: c3, c3H, D7Ssb3Hp, Tyrc-3H
Gene: Del(7)Tyrc-3H  Location: unknown  Genetic Position: Chr7, Syntenic
Strain of Origin:  (C3H/HeH x 101/H)F1
Allele Type:    Radiation induced
Mutation:    Intergenic deletion
    Large intergenic deletion. (J:6053)
Inheritance:    Not Specified
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(7)Tyrc-3H Mutation:  0 strains or lines available
This allele resembles two other induced mutant alleles, Tyrc-65K and Tyrc-112K, in most respects studied, including neonatal death, effect on liver enzymes and serum proteins (J:5435), and defective rough endoplasmic reticulum of liver (J:5386). Liver cells of homozygotes have reduced numbers of receptors for epidermal growth factor and glucagon (J:12047), and three specific liver polypeptides recognizable in two-dimensional gels are lacking (J:7420). Kidneys are severely reduced in size, but there are very few thymus abnormalities (J:5063). The deletion includes the Mod2 locus (J:6053). Heterozygous Tyrc-3H/Tyrc-6H mice are viable, but runted and sterile (J:6034). They have been used to study the effects of absence of mitochondrial malic enzyme caused by the absence of the Mod2 locus (J:6351).

Compound heterozygotes carrying Tyrc-ch show dilution of the chinchilla pigmentation compared to homozygous chinchilla mice (Tyrc-ch/Tyrc-ch, J:5435).

Original:  J:5063 Erickson RP, et al., Glucose-6-phosphatase deficiency caused by radiation-induced alleles at the albino locus in the mouse. Proc Natl Acad Sci U S A. 1968 Feb;59(2):437-44
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.22
The Jackson Laboratory