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Spontaneous Allele Detail
Symbol: Tyrc-Bc
Name: tyrosinase; albino British Columbia
MGI ID: MGI:1856301
Synonyms: cBc
Gene: Tyr  Location: Chr7:87427405-87493411 bp, - strand  Genetic Position: Chr7, 49.01 cM
Strain of Origin:  SELH/Bc
Allele Type:    Spontaneous
Mutation:    Intergenic deletion
Mutation detailsThis allele involves a deletion of as much as 2 cM including exons 1, 2, and 3 of Tyr, the Mod-2 locus and a gene essential for postimplantation survival. (J:18053)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tyr Mutation:  347 strains or lines available
Tyrc-Bc, albino British Columbia, recessive. This spontaneous mutation arose in a male that appeared to be a somatic and germ line mosaic for the new albino allele. Homozygotes die soon after implantation. There is no activity of the Mod2 allele in cis with Tyrc-Bc, and it is concluded that this mutation represents a deletion including the Tyr locus, Mod2, and a hypothetical locus essential for postimplantation survival (J:62). The Tyrc-Bc mutation is a deletion of exons 1, 2, and 3, along with other Chr 7 loci (J:18053).

Original:  J:62 Juriloff DM, et al., Studies of a spontaneous lethal mutation at the albino locus in SELH/Bc mice. Genome. 1992 Apr;35(2):342-6
All:  2 reference(s)

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MGI 6.01
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