Kit^W-sh
Spontaneous Allele Detail

Summary

• Symbol: Kit^W-sh
• Name: KIT proto-oncogene receptor tyrosine kinase; sash
• MGI ID: MGI:1856265
• Synonyms: c-Kit^wsh, Sash, Wsh, W^sh, W-sh
• Gene: Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Kit^W-sh page

Mutation origin

• Strain of Origin: (C3H/HeH x 101/H)F1

Mutation description

• Allele Type: Spontaneous
• Mutation: Inversion
• Kit^W-sh involves 32 genes/genome features (Tec, Slain2, Slc10a4 ...) View all
• Mutation details: The molecular mutation of this allele is an inversion located proximal to the Kit structural gene that disrupts 5' regulatory sequences. Transcripts were not detectable from this allele in cultured mast cells derived from homozygous mice. However, an analysis of embryonic expression revealed that ectopic expression of Kit occurred in homozygous mice and normal expression was ablated. (J:2535, J:6857, J:13166, J:25082, J:29686)
• Inheritance: Semidominant

Disease models

Expression

In Mice Carrying this Mutation:

93 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 11 strains available Cell Lines: 0 lines available
• Carrying any Kit Mutation: 179 strains or lines available

References

• Original: J:6857 Lyon MF, et al., A new allele sash (Wsh) at the W-locus and a spontaneous recessive lethal in mice. Genet Res. 1982 Jun;39(3):315-22
• All: 324 reference(s)