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KitW-sh
Spontaneous Allele Detail
Nomenclature
Symbol: KitW-sh
Name: kit oncogene; sash
MGI ID: MGI:1856265
Synonyms: Sash, Wsh, Wsh, W-sh
Gene: Kit  Location: Chr5:75574916-75656722 bp, + strand  Genetic Position: Chr5, 39.55 cM
Mutation
origin
Strain of Origin:  (C3H/HeH x 101/H)F1
Mutation
description
Allele Type:    Spontaneous
Mutation:    Inversion
 
Mutation detailsThe molecular mutation of this allele is an inversion located proximal to the Kit structural gene that disrupts 5' regulatory sequences. Transcripts were not detectable from this allele in cultured mast cells derived from homozygous mice. However, an analysis of embryonic expression revealed that ectopic expression of Kit occurred in homozygous mice and normal expression was ablated. (J:2535, J:6857, J:13166, J:25082, J:29686)
Inheritance:    Semidominant
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 93 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 12 strains available      Cell Lines: 0 lines available
Carrying any Kit Mutation:  116 strains or lines available
References
Original:  J:6857 Lyon MF, et al., A new allele sash (Wsh) at the W-locus and a spontaneous recessive lethal in mice. Genet Res. 1982 Jun;39(3):315-22
All:  192 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory