About   Help   FAQ
Galctwi
Spontaneous Allele Detail
Nomenclature
Symbol: Galctwi
Name: galactosylceramidase; twitcher
MGI ID: MGI:1856218
Synonyms: galc-, twi
Gene: Galc  Location: Chr12:98202304-98259459 bp, - strand  Genetic Position: Chr12, 49.83 cM
Mutation
origin
Strain of Origin:  CE/J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsSequence analysis comparisons of cDNA from livers of mice homozygous for this allele and +/+ mice showed a G to A transition at codon 339. Northern analysis showed absence of the most abundant mRNA of mouse galactocerebrosidase in mice homozygous for this allele. (J:31433)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Galc Mutation:  5 strains or lines available
References
Original:  J:13867 Duchen LW, A new neurological mutant "twitcher" (twi). Mouse News Lett. 1979;61:47
All:  74 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory