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KitlSl-d
Spontaneous Allele Detail
Nomenclature
Symbol: KitlSl-d
Name: kit ligand; steel Dickie
MGI ID: MGI:1856164
Synonyms: KL, MGF, MgfSl-d, Sld, Sld, W/Wv
Gene: Kitl  Location: Chr10:100015630-100100416 bp, + strand  Genetic Position: Chr10, 51.4 cM
KitlSl/KitlSl-d mouse

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  DBA/2J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsA 4kb deletion in genomic DNA results in the absence of 241bp in the mRNA and the addition of 67bp of novel sequence, a 174bp net loss. The region that is deleted corresponds to 5 amino acids N-terminal to the transmembrane domain of the encoded protein, and results in termination of the open reading frame after an additional 3 amino acids. The resulting protein is a soluble truncated one, lacking both transmembrane and cytoplasmic domains. Northern analysis indicates that mRNA is transcribed at nearly wild-type levels in adult tissues. (J:10750, J:20286, J:40339)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 24 assay results
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Kitl Mutation:  30 strains or lines available
Notes

Genbank ID for this allele: M64262

References
Original:  J:13392 Bernstein S, Steel Dickie. Mouse News Lett. 1960;23:33-4
All:  73 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory