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KitlSl
Spontaneous Allele Detail
Nomenclature
Symbol: KitlSl
Name: kit ligand; steel
MGI ID: MGI:1856161
Synonyms: MgfSl, Sl
Gene: Kitl  Location: Chr10:100015630-100100416 bp, + strand  Genetic Position: Chr10, 51.4 cM
Pax3Sp/+ and KitlSl/+

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C3H
Mutation
description
Allele Type:    Spontaneous
Mutation:    Deletion
  KitlSl involves 1 genes/genome features (Kitl) View all
 
Mutation detailsBy Southern blotting, it was concluded that this allele contains a deletion encompassing most, if not all, of the coding region of the gene. A probe corresponding to nucleotides 6 to 685 of the cDNA failed to hybridize to DNA obtained from embryos homozygous for this allele. PCR analysis with primers for sequences at various distances from the Kit gene narrowed the 5' and 3' deletion endpoints to a 350 and a 380 base-pair region, respectively. Sequencing of the product of PCR using primers designed to span the deletion revealed that it extends through 973,366 base pairs on Chromosome 10 between nucleotide positions 99,177,807 and 100,151,173 (NCBI Map Viewer, Build 36.1), with a 4-base pair insertion joining the deletion endpoints, and contains 6 predicted and 3 known genes. (J:10750, J:115283)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 18 assay results
In Structures Affected by this Mutation: 19 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Kitl Mutation:  30 strains or lines available
References
Original:  J:3399 Sarvella PA, et al., Steel, a new dominant gene in the house mouse. J Hered. 1956;47:123-128
All:  69 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory