KitlSl
Spontaneous Allele Detail
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Symbol: |
KitlSl |
Name: |
kit ligand; steel |
MGI ID: |
MGI:1856161 |
Synonyms: |
MgfSl, Sl |
Gene: |
Kitl Location: Chr10:99851492-99936278 bp, + strand Genetic Position: Chr10, 51.4 cM
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Alliance: |
KitlSl page
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Pax3Sp/+ and KitlSl/+
Show the 2 phenotype image(s) involving this allele.
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Allele Type: |
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Spontaneous |
Mutation: |
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Deletion
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KitlSl involves 1 genes/genome features (Kitl)
View all
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Mutation details: By Southern blotting, it was concluded that this allele contains a deletion encompassing most, if not all, of the coding region of the gene. A probe corresponding to nucleotides 6 to 685 of the cDNA failed to hybridize to DNA obtained from embryos homozygous for this allele. PCR analysis with primers for sequences at various distances from the Kit gene narrowed the 5' and 3' deletion endpoints to a 350 and a 380 base-pair region, respectively. Sequencing of the product of PCR using primers designed to span the deletion revealed that it extends through 973,366 base pairs on Chromosome 10 between nucleotide positions 99,177,807 and 100,151,173 (NCBI Map Viewer, Build 36.1), with a 4-base pair insertion joining the deletion endpoints, and contains 6 predicted and 3 known genes.
(J:10750, J:115283)
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Inheritance: |
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Semidominant |
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View phenotypes and curated references for all genotypes (concatenated display).
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List all tumor models in MMHCdb carrying
KitlSl
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Original: |
J:3399 Sarvella PA, et al., Steel, a new dominant gene in the house mouse: With effects on coat pigment and blood. J Hered. 1956;47(3):123-128 |
All: |
73 reference(s) |
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