Mitf^mi-ew
Spontaneous Allele Detail

Summary

• Symbol: Mitf^mi-ew
• Name: melanogenesis associated transcription factor; eyeless white
• MGI ID: MGI:1856094
• Synonyms: mi^ew
• Gene: Mitf Location: Chr6:97784013-97998310 bp, + strand Genetic Position: Chr6, 45.05 cM
• Alliance: Mitf^mi-ew page

Mutation origin

• Strain of Origin: C57BL/6Bn

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A-to-T transversion four nucleotides downstream of the exon 6b donor site. This mutation is likely to be sufficient to abolish normal splicing, leading to exon skipping and an mRNA missing exons 6a/6b. (J:21366, J:62098)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	27 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mitf Mutation: 72 strains or lines available

Notes

Mitf^mi-ew, eyeless white, recessive. This mutation occurred spontaneously at the University of Kansas. Homozygotes have white coat color. The eyes are undeveloped and eyelids never open. Heterozygotes with various other Mitf mutations have been described (J:30755). The DNA lesion is a deletion of a portion of the Mitf gene, including the basic region (J:21366).

References

• Original: J:30755 Wood BC, et al., Mitf. Mouse News Lett. 1969;40:32
• All: 14 reference(s)