Acan^cmd-Bc
Spontaneous Allele Detail

Summary

• Symbol: Acan^cmd-Bc
• Name: aggrecan; cartilage matrix deficiency British Columbia
• MGI ID: MGI:1855999
• Synonyms: cmd-Bc
• Gene: Acan Location: Chr7:78703231-78764847 bp, + strand Genetic Position: Chr7, 44.88 cM
• Alliance: Acan^cmd-Bc page

Mutation origin

• Strain of Origin: BALB/cGaBc

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: This allele comprises a deletion resulting in the complete loss of exons 2 to 18, resulting in a significantly shortened mRNA. The upstream breakpoint is in intron 1, 18.8 kb 3' of exon 1; the downstream breakpoint lies 10.5 kb past the final aggrecan exon 18. (J:58755)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acan Mutation: 77 strains or lines available

References

• Original: J:65316 Juriloff DM, et al., Agc^cmd-Bc - cartilage matrix deficiency-British Columbia. Mouse News Lett. 1985;72:95
• All: 5 reference(s)