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Radiation induced Allele Detail
Symbol: Crygenz
Name: crystallin, gamma E; dominant cataract 2, nuclear and zonular opacity
MGI ID: MGI:1855995
Synonyms: Cat2nz, CrygeCat2-nz, Nzc
Gene: Cryge  Location: Chr1:65048554-65051149 bp, - strand  Genetic Position: Chr1, 32.8 cM
Strain of Origin:  (101 x C3H)F1
Allele Type:    Radiation induced
Mutation:    Intragenic deletion
Mutation detailsA deletion of a T at position 89 in the encoded mRNA leads to a change in the open reading frame. The mutated sequence encodes a novel peptide of 125 amino acids, as detected in Western blotting of lens extracts derived from mutant mice. (J:66541)
Inheritance:    Semidominant
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cryge Mutation:  8 strains or lines available
Arose in descendants of irradiated mice. This mutation causes less severe defects than other Cat2 alleles.

Phenotypic Similarity to Human Syndrome: Dominant Cataracts in heterozygous and homozygous mice (J:6686, J:9528)

Original:  J:6686 Kratochvilova J, Dominant cataract mutations detected in offspring of gamma-irradiated male mice. J Hered. 1981 Sep-Oct;72(5):302-7
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory