About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Spontaneous Allele Detail
Symbol: Gdf5bp-J
Name: growth differentiation factor 5; brachypodism Jackson
MGI ID: MGI:1855974
Synonyms: GdfbpJ
Gene: Gdf5  Location: Chr2:155941023-155945367 bp, - strand  Genetic Position: Chr2, 77.26 cM

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  A/J
Allele Type:    Spontaneous
Mutation:    Insertion
Mutation detailsThis remutation to brachypodism occurred in the A/J strain at The Jackson Laboratory. The mutation is caused by the insertion of a guanine residue into a stretch of three guanine residues in the gene sequence (position 1444-1448), producing a stop codon 41 amino acids later. (J:17582)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gdf5 Mutation:  12 strains or lines available
The long bones of the limbs of mutant mice are slightly shorter than controls, and the fibula is shortened proximally. The bones of the axial skeleton are unaffected.

Original:  J:17582 Storm EE, et al., Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily [see comments]. Nature. 1994 Apr 14;368(6472):639-43
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.21
The Jackson Laboratory