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Tyrp1b
Spontaneous Allele Detail
Nomenclature
Symbol: Tyrp1b
Name: tyrosinase-related protein 1; brown
MGI ID: MGI:1855960
Synonyms: b
Gene: Tyrp1  Location: Chr4:80834123-80851719 bp, + strand  Genetic Position: Chr4, 37.89 cM
a/a Tyrp1b/Tyrp1b

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  old mutant of the mouse fancy
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsA G-to-A transition point mutation at position 329 was shown by revertant analysis to be responsible for the mutant phenotype seen in the brown mutant. This mutation is predicted to change a cysteine residue to a tyrosine in the encoded protein. Three other point mutations in the brown sequence were identified, but do not contribute to the mutant phenotype. (J:44435)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 33 strains available      Cell Lines: 0 lines available
Carrying any Tyrp1 Mutation:  92 strains or lines available
References
Original:  J:30758 Gruneberg H, in The Genetics of the Mouse. 1952
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory