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Spontaneous Allele Detail
Symbol: Ahvy
Name: nonagouti; hypervariable yellow
MGI ID: MGI:1855945
Gene: a  Location: Chr2:154791402-155051012 bp, + strand  Genetic Position: Chr2, 76.83 cM
Strain of Origin:  C3H/HeJ
Allele Type:    Spontaneous
Mutation:    Transposon insertion
Mutation detailsSequencing of 5' RACE and genomic PCR products revealed that this allele resulted from the integration of an intracisternal A particle (IAP) in an antisense orientation within the 5'untranslated region of exon 1C. Methylation assay results indciate that the agouti and yellow mosaic phenotype characteristic of this allele is due to differential epigenetic methylation of the IAP. (J:31145, J:79708)
Inheritance:    Dominant
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any a Mutation:  364 strains or lines available
Original:  J:24247 Siracusa LD, et al., Hypervariable yellow (Ahvy), a new murine agouti mutation: Ahvy displays the largest variation in coat color phenotypes of all known agouti alleles. J Hered. 1995 Mar-Apr;86(2):121-8
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory