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Spontaneous Allele Detail
Symbol: Avy
Name: nonagouti; agouti viable yellow
MGI ID: MGI:1855930
Gene: a  Location: Chr2:154791402-155051012 bp, + strand  Genetic Position: Chr2, 76.83 cM
Spectrum of coat colors in Avy/a mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  C3H/HeJ
Allele Type:    Spontaneous
Mutation:    Transposon insertion
Mutation detailsAn intracisternal A particle (IAP) retrotransposon is inserted 100kb upstream of agouti coding sequences causing ectopic, allele-specific imprinting of agouti protein expression. (J:19977, J:21244, J:79708)
Inheritance:    Dominant
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any a Mutation:  349 strains or lines available
The Avy allele arose spontaneously in the C3H/HeJ strain. Avy resembles Ay except that homozygotes are viable and resemble heterozygotes with lower members of the series. Both homozygotes (Avy/Avy) and heterozygotes (Avy/A and Avy/a) show considerable variation in appearance, ranging from clear yellow, through mottling with dark patches, to a completely agouti-like coat (J:5475). The variation is strongly influenced by the agouti-locus genotype and strain genome of the dam (J:6103). A larger proportion of homozygotes than heterozygotes are clear yellow (J:13080). In combination with the dominant spotting allele KitW-2J, Avy heterozygotes that have the agouti phenotype have much larger white spots than those of yellow or mottled yellow phenotype (J:12035). Homozygotes and heterozygotes tend to become obese, and the degree of obesity is correlated with the amount of yellow in the coat (J:13142), except that Eso prevents synthesis of yellow pigment in Avy/- mice but does not prevent obesity (J:6103). Avy resembles a in causing greater tumor susceptibility and lower graft vs. host reactivity (J:5320) and higher hepatic malic enzyme activity (J:5759). The greater tumor susceptibility as well as several altered immune responses occur in Avy/a mice of mottled phenotype but not in those of agouti phenotype (J:7421).

Genbank ID for this mutation: S74479

Original:  J:13080 DICKIES MM, A new viable yellow mutation in the house mouse. J Hered. 1962 Mar-Apr;53:84-6
All:  58 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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