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Tgfbi Gene Detail
Summary
  • Symbol
    Tgfbi
  • Name
    transforming growth factor, beta induced
  • Synonyms
    68kDa, Beta-ig, bIG-h3
  • Feature Type
    protein coding gene
  • IDs
    MGI:99959
    NCBI Gene: 21810
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:56757399-56787172 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 30.09 cM, cytoband B-C1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    248 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99959
 protein coding gene Chr13:56757336-56787375 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020622
 protein coding gene Chr13:56177852-56207570 (+)
A/J MGP_AJ_G0020576
 protein coding gene Chr13:54081295-54110861 (+)
AKR/J MGP_AKRJ_G0020554
 protein coding gene Chr13:55681001-55710994 (+)
BALB/cJ MGP_BALBcJ_G0020572
 protein coding gene Chr13:54317954-54348016 (+)
C3H/HeJ MGP_C3HHeJ_G0020371
 protein coding gene Chr13:55489687-55525923 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021006
 protein coding gene Chr13:57868841-57898618 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018588
 protein coding gene Chr13:52017427-52048750 (+)
CAST/EiJ MGP_CASTEiJ_G0019885
 protein coding gene Chr13:55619897-55707982 (+)
CBA/J MGP_CBAJ_G0020331
 protein coding gene Chr13:60090629-60123824 (+)
DBA/2J MGP_DBA2J_G0020454
 protein coding gene Chr13:53628448-53658114 (+)
FVB/NJ MGP_FVBNJ_G0020433
 protein coding gene Chr13:53100669-53132089 (+)
LP/J MGP_LPJ_G0020530
 protein coding gene Chr13:56424587-56455491 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020462
 protein coding gene Chr13:59488530-59518230 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021049
 protein coding gene Chr13:55273054-55302701 (+)
PWK/PhJ MGP_PWKPhJ_G0019641
 protein coding gene Chr13:53673435-53703813 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019468
 protein coding gene Chr13:54218105-54251422 (+)
WSB/EiJ MGP_WSBEiJ_G0019947
 protein coding gene Chr13:55640892-55674483 (+)



Homology
more
  • Human Ortholog
    TGFBI, transforming growth factor beta induced
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TGFBI, transforming growth factor beta induced
  • Synonyms
    BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1
  • Links
    NCBI Gene ID: 7045
    neXtProt AC: NX_Q15582
    UniProt: Q15582

  • Chr Location
    5q31.1; chr5:136028988-136063818 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tgfbi mouse models; 6 with human TGFBI associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 4 alleles in 5 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show delayed growth and are prone to spontaneous and induced tumors. Homozygotes for a second null allele are prone to STZ-induced diabetes and show impaired islet function under stress. Homozygotes for a third null allele show a transient decrease in retinal apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1554
  • Tissues
    481
  • cDNA Data
    147
  • Literature Summary
    40
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21810 NCBI Gene Model | MGI Sequence Detail 29774 C57BL/6J ±  kb
    transcript NR_155548 RefSeq | MGI Sequence Detail 2737 ZRU/MplStud  
    polypeptide P82198 UniProt | EBI | MGI Sequence Detail 683 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 154
      cDNA 148
      Primer pair 4
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-16764, MGI:2145190, MGI:2145285
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 40
      Diseases 1
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:344566 Zanini F, et al., Hyperoxia prevents the dynamic neonatal increases in lung mesenchymal cell diversity. Sci Rep. 2024 Jan 23;14(1):2033
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory