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Creb3 Gene Detail
Summary
  • Symbol
    Creb3
  • Name
    cAMP responsive element binding protein 3
  • Synonyms
    Luman, LZIP, LZIP-1, LZIP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:99946
    NCBI Gene: 12913
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:43562658-43567061 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 23.05 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    31 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99946
 protein coding gene Chr4:43562332-43567061 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028213
 protein coding gene Chr4:41684052-41688777 (+)
A/J MGP_AJ_G0028169
 protein coding gene Chr4:40204030-40208750 (+)
AKR/J MGP_AKRJ_G0028121
 protein coding gene Chr4:41116244-41120967 (+)
BALB/cJ MGP_BALBcJ_G0028189
 protein coding gene Chr4:40294112-40298832 (+)
C3H/HeJ MGP_C3HHeJ_G0027911
 protein coding gene Chr4:41745870-41750590 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028630
 protein coding gene Chr4:43246305-43251033 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025942
 protein coding gene Chr4:37652103-37656975 (+)
CAST/EiJ MGP_CASTEiJ_G0027351
 protein coding gene Chr4:41251485-41256202 (+)
CBA/J MGP_CBAJ_G0027877
 protein coding gene Chr4:44565163-44569883 (+)
DBA/2J MGP_DBA2J_G0028026
 protein coding gene Chr4:40113813-40118533 (+)
FVB/NJ MGP_FVBNJ_G0027993
 protein coding gene Chr4:39336591-39341311 (+)
LP/J MGP_LPJ_G0028125
 protein coding gene Chr4:41740846-41745574 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028017
 protein coding gene Chr4:47819923-47824646 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028666
 protein coding gene Chr4:41318230-41322949 (+)
PWK/PhJ MGP_PWKPhJ_G0027077
 protein coding gene Chr4:40156423-40161147 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026903
 protein coding gene Chr4:40880906-40884996 (+)
WSB/EiJ MGP_WSBEiJ_G0027431
 protein coding gene Chr4:41218744-41223470 (+)



Homology
more
  • Human Ortholog
    CREB3, cAMP responsive element binding protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CREB3, cAMP responsive element binding protein 3
  • Synonyms
    LUMAN, LZIP, sLZIP
  • Links
    NCBI Gene ID: 10488
    neXtProt AC: NX_O43889
    UniProt: O43889

  • Chr Location
    9p13.3; chr9:35732598-35736999 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are sub-viable. Heterozygotes are resistant to high-fat diet-induced obesity and hepatic steatosis and show increased energy expenditure and respiratory exchange ratios, altered hepatic lipid profiles, but maintain normal glucose levels on a high-fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    74
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    893
  • Tissues
    84
  • cDNA Data
    19
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12913 NCBI Gene Model | MGI Sequence Detail 4404 C57BL/6J ±  kb
    transcript NM_013497 RefSeq | MGI Sequence Detail 1559 ZRU/MplStud  
    polypeptide Q61817 UniProt | EBI | MGI Sequence Detail 404 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 19
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-16749, MGI:2140496, MGI:2140584, MGI:2140683
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 11
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:17005 Burbelo PD, et al., LZIP-1 and LZIP-2: two novel members of the bZIP family. Gene. 1994 Feb 25;139(2):241-5
    • Latest
      J:344828 Smith BS, et al., ER stress-associated transcription factor CREB3 is essential for normal Ca(2+), ATP, and ROS homeostasis. Mitochondrion. 2023 Mar;69:10-17
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory