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Adcy3 Gene Detail
Summary
  • Symbol
    Adcy3
  • Name
    adenylate cyclase 3
  • Synonyms
    AC3, ACIII, mKIAA0511
  • Feature Type
    protein coding gene
  • IDs
    MGI:99675
    NCBI Gene: 104111
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:4183397-4263525 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 1.99 cM, cytoband A-B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    489 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99675
 protein coding gene Chr12:4183103-4263525 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019564
 protein coding gene Chr12:995833-1081138 (+)
A/J MGP_AJ_G0019531
 protein coding gene Chr12:1017470-1099275 (+)
AKR/J MGP_AKRJ_G0019501
 protein coding gene Chr12:1167787-1255700 (+)
BALB/cJ MGP_BALBcJ_G0019506
 protein coding gene Chr12:1038988-1115991 (+)
C3H/HeJ MGP_C3HHeJ_G0019312
 protein coding gene Chr12:954014-1043002 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019955
 protein coding gene Chr12:1016411-1110830 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017580
 protein coding gene Chr12:922463-1001300 (+)
CAST/EiJ MGP_CASTEiJ_G0018867
 protein coding gene Chr12:1028127-1110118 (+)
CBA/J MGP_CBAJ_G0019283
 protein coding gene Chr12:1268888-1381630 (+)
DBA/2J MGP_DBA2J_G0019396
 protein coding gene Chr12:952958-1033150 (+)
FVB/NJ MGP_FVBNJ_G0019386
 protein coding gene Chr12:978355-1057679 (+)
LP/J MGP_LPJ_G0019467
 protein coding gene Chr12:1015527-1098417 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019420
 protein coding gene Chr12:1082782-1165626 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019994
 protein coding gene Chr12:948136-1037089 (+)
PWK/PhJ MGP_PWKPhJ_G0018633
 protein coding gene Chr12:979323-1061426 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018424
 protein coding gene Chr12:1022738-1103659 (+)
WSB/EiJ MGP_WSBEiJ_G0018919
 protein coding gene Chr12:979399-1061992 (+)



Homology
more
  • Human Ortholog
    ADCY3, adenylate cyclase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADCY3, adenylate cyclase 3
  • Synonyms
    AC3, AC-III, BMIQ19
  • Links
    NCBI Gene ID: 109
    neXtProt AC: NX_O60266
    UniProt: O60266

  • Chr Location
    2p23.3; chr2:24819169-24920237 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Adcy3 mouse models; 1 with human ADCY3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    66 phenotypes from 7 alleles in 10 genetic backgrounds
    10 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one mutation of this gene display impaired olfaction and disorganization of glomeruli in the main olfactory bulb. Mutant animals also appear to be sterile as homozygous matings failed to produce litters. Mice with another mutant allele fail to survive beyond weaning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1267
  • Tissues
    264
  • cDNA Data
    10
  • Literature Summary
    64
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 104111 NCBI Gene Model | MGI Sequence Detail 80129 C57BL/6J ±  kb
    transcript NM_001422786 RefSeq | MGI Sequence Detail 4732 C57BL/6  
    polypeptide Q8VHH7 UniProt | EBI | MGI Sequence Detail 1145 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 11
      Primer pair 3
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16460
    References
    more
    • Summaries
      All 139
      Developmental Gene Expression 64
      Diseases 1
      Gene Ontology 14
      Phenotypes 47
    • Earliest
      J:22804 Edelhoff S, et al., Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse. Mamm Genome. 1995 Feb;6(2):111-3
    • Latest
      J:341298 Chen T, et al., Adenylyl cyclase 3 deficiency results in dysfunction of blood-testis barrier during mouse spermiogenesis. Theriogenology. 2022 Mar 1;180:40-52
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory