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Prdm1 Gene Detail
Summary
  • Symbol
    Prdm1
  • Name
    PR domain containing 1, with ZNF domain
  • Synonyms
    b2b1765Clo, Blimp1, Blimp-1, PRDI-BF1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99655
    NCBI Gene: 12142
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:44313173-44404497 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 23.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    432 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99655
 protein coding gene Chr10:44313170-44404579 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017205
 protein coding gene Chr10:43293342-43388616 (-)
A/J MGP_AJ_G0017181
 protein coding gene Chr10:42067143-42159375 (-)
AKR/J MGP_AKRJ_G0017140
 protein coding gene Chr10:42734754-42841866 (-)
BALB/cJ MGP_BALBcJ_G0017142
 protein coding gene Chr10:42126140-42218862 (-)
C3H/HeJ MGP_C3HHeJ_G0016966
 protein coding gene Chr10:43050729-43145047 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017600
 protein coding gene Chr10:44602582-44698699 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015295
 protein coding gene Chr10:39984868-40081153 (-)
CAST/EiJ MGP_CASTEiJ_G0016540
 protein coding gene Chr10:43300199-43399128 (-)
CBA/J MGP_CBAJ_G0016937
 protein coding gene Chr10:46616406-46713867 (-)
DBA/2J MGP_DBA2J_G0017042
 protein coding gene Chr10:41501008-41592677 (-)
FVB/NJ MGP_FVBNJ_G0017036
 protein coding gene Chr10:41009264-41105112 (-)
LP/J MGP_LPJ_G0017117
 protein coding gene Chr10:43321155-43416626 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017065
 protein coding gene Chr10:47303845-47397704 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017636
 protein coding gene Chr10:42740600-42834904 (-)
PWK/PhJ MGP_PWKPhJ_G0016319
 protein coding gene Chr10:41460434-41554534 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016104
 protein coding gene Chr10:42564029-42656342 (-)
WSB/EiJ MGP_WSBEiJ_G0016603
 protein coding gene Chr10:42984791-43079540 (-)



Homology
more
  • Human Ortholog
    PRDM1, PR/SET domain 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRDM1, PR/SET domain 1
  • Synonyms
    BLIMP1, PRDI-BF1
  • Links
    NCBI Gene ID: 639
    neXtProt AC: NX_O75626
    UniProt: O75626

  • Chr Location
    6q21; chr6:105992690-106109939 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Prdm1 mouse models; 2 with human PRDM1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    70 phenotypes from 11 alleles in 12 genetic backgrounds
    20 phenotypes from multigenic genotypes
    13 images
    243 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality and impaired primordial germ cell development, while heterozygotes display a decreased numbers of primordial germ cells but normal migration. Conditional mutants display impaired plasma cell and pre-plasmamemory B cell development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    76
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1100
  • Tissues
    225
  • cDNA Data
    39
  • Literature Summary
    82
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038151 Ensembl Gene Model | MGI Sequence Detail 91325 C57BL/6J ±  kb
    transcript ENSMUST00000039174 Ensembl | MGI Sequence Detail 5281 Not Applicable  
    polypeptide ENSMUSP00000039248 Ensembl | MGI Sequence Detail 856 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 41
      Primer pair 5
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16440, MGI:5446148
    References
    more
    • Summaries
      All 384
      Developmental Gene Expression 82
      Diseases 2
      Gene Ontology 21
      Phenotypes 243
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:342346 Hayashi Y, et al., Nutritional and metabolic control of germ cell fate through O-GlcNAc regulation. EMBO Rep. 2023 Nov 6;24(11):e56845
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory