Cdh13 MGI Mouse Gene Detail - MGI:99551

Symbol

Cdh13
Name

cadherin 13
Synonyms

4932416G01Rik, Tcad, T-cadherin

Feature Type

protein coding gene
IDs

MGI:99551
NCBI Gene: 12554
Alliance

gene page
Transcription Start Sites

25 TSS

Sequence Map

Chr8:119010472-120051660 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 65.97 cM
Mapping Data

2 experiments

SNPs within 2kb

4427 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99551	protein coding gene	Chr8:119010150-120051668 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034178	protein coding gene	Chr8:121532477-122627771 (+)
A/J	MGP_AJ_G0034158	protein coding gene	Chr8:116532400-117591573 (+)
AKR/J	MGP_AKRJ_G0034085	protein coding gene	Chr8:119933646-121013788 (+)
BALB/cJ	MGP_BALBcJ_G0034152	protein coding gene	Chr8:116745480-117800025 (+)
C3H/HeJ	MGP_C3HHeJ_G0033863	protein coding gene	Chr8:120663893-121735193 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034672	protein coding gene	Chr8:125621798-126731779 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031614	protein coding gene	Chr8:109460134-110491361 (+)
CAST/EiJ	MGP_CASTEiJ_G0033190	protein coding gene	Chr8:120560822-121670357 (+)
CBA/J	MGP_CBAJ_G0033836	protein coding gene	Chr8:130183319-131355520 (+)
DBA/2J	MGP_DBA2J_G0033992	protein coding gene	Chr8:115765426-116815736 (+)
FVB/NJ	MGP_FVBNJ_G0033935	protein coding gene	Chr8:114781720-115827837 (+)
LP/J	MGP_LPJ_G0034081	protein coding gene	Chr8:121666836-122780457 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033982	protein coding gene	Chr8:132714441-133814599 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034690	protein coding gene	Chr8:120066291-121160986 (+)
PWK/PhJ	MGP_PWKPhJ_G0032892	protein coding gene	Chr8:115507736-116573440 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032732	protein coding gene	Chr8:118751587-119852910 (+)
WSB/EiJ	MGP_WSBEiJ_G0033306	protein coding gene	Chr8:120773899-121873701 (+)

Human Ortholog

CDH13, cadherin 13

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDH13, cadherin 13
Synonyms

CDHH, P105
Links

HGNC:1753

NCBI Gene ID: 1012

neXtProt AC: NX_P55290

UniProt: P55290
Chr Location

16q23.3; chr16:82626965-83800640 (+) GRCh38

MGI Vertebrate Homology

Cdh13 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDH13
Gene Tree

Cdh13

Diseases

8 with human CDH13 associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				breast carcinoma IDs breast carcinoma DOID:3459 EFO:0000305 MESH:D001943 NCI:C4872 UMLS_CUI:C0678222
				cervical cancer IDs cervical cancer DOID:4362 DOID:4361 ICD10CM:C53 ICD9CM:180 ICD9CM:180.9 MESH:D002583 NCI:C2940 NCI:C9311 OMIM:603956 UMLS_CUI:C0007847 UMLS_CUI:C0007873
				endometrial carcinoma IDs endometrial carcinoma DOID:2871 DOID:3000 MESH:D016889 MESH:D018269 NCI:C7558 UMLS_CUI:C0206687 UMLS_CUI:C0476089
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131
				ovarian cancer IDs ovarian cancer DOID:2394 DOID:0060070 DOID:2144 DOID:9595 ICD10CM:C56 ICD9CM:183.0 MESH:D010051 NCI:C4984 NCI:C7431 OMIM:167000 OMIM:607893 ORDO:213500 ORDO:213517 UMLS_CUI:C0919267 UMLS_CUI:C1140680 UMLS_CUI:C1299247
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358
				urinary bladder cancer IDs urinary bladder cancer DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 3 alleles in 3 genetic backgrounds
7 phenotypes from multigenic genotypes
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

3
Gene trapped

2
Targeted

10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased retinal neovascularization and increased adiponectin levels.

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All GO Annotations

70
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1112
Tissues

176
cDNA Data

65
Literature Summary

28

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDH13

Xenbase cdh13

ZFIN cdh13

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All Sequences

58
RefSeq

6
UniProt

3
CCDS

CCDS52682.1

Ensembl

ENSMUSG00000031841 (Evidence)
NCBI Gene

12554

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031841	Ensembl Gene Model \| MGI Sequence Detail	1041189	C57BL/6J	± kb
transcript	ENSMUST00000117160	Ensembl \| MGI Sequence Detail	3785	Not Applicable
polypeptide	ENSMUSP00000113527	Ensembl \| MGI Sequence Detail	714	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005232 cadherin-13

(term hierarchy)
PDB

3K5R, 3K6F
InterPro Domains

IPR039808 Cadherin

IPR020894 Cadherin conserved site

IPR002126 Cadherin-like

IPR015919 Cadherin-like superfamily

IPR014868 Cadherin prodomain

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All nucleic 73

cDNA 71

Primer pair 1

Other 1

Microarray probesets 9

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MGD-MRK-16329, MGD-MRK-19363, MGI:1921623

Summaries

All 84

Developmental Gene Expression 28

Gene Ontology 6

Phenotypes 28
Earliest

J:32957 Munro SB, et al., Characterization of cadherins expressed by murine thymocytes. Cell Immunol. 1996 May 1;169(2):309-12
Latest

J:344012 Sakaue TA, et al., Adiponectin accumulation in the retinal vascular endothelium and its possible role in preventing early diabetic microvascular damage. Sci Rep. 2022 Mar 9;12(1):4159

TSS for Cdh13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79649	Chr8:119010327-119010341 (+)	-138 bp
Tssr79650	Chr8:119010346-119010357 (+)	-120 bp
Tssr79651	Chr8:119010362-119010372 (+)	-105 bp
Tssr79652	Chr8:119010392-119010403 (+)	-74 bp
Tssr79653	Chr8:119010458-119010477 (+)	-4 bp
Tssr79654	Chr8:119010483-119010506 (+)	23 bp
Tssr79655	Chr8:119010528-119010542 (+)	63 bp
Tssr79656	Chr8:119036142-119036163 (+)	25,681 bp
Tssr79657	Chr8:119080986-119080989 (+)	70,516 bp
Tssr2699	Chr8:119164858-119164870 (+)	154,392 bp
Tssr79658	Chr8:119170375-119170377 (+)	159,904 bp
Tssr79659	Chr8:119197392-119197419 (+)	186,934 bp
Tssr79660	Chr8:119276443-119276444 (+)	265,972 bp
Tssr79661	Chr8:119288176-119288179 (+)	277,706 bp
Tssr79662	Chr8:119460123-119460127 (+)	449,653 bp
Tssr79663	Chr8:119526125-119526133 (+)	515,657 bp
Tssr79664	Chr8:119617915-119617921 (+)	607,446 bp
Tssr79665	Chr8:119697128-119697132 (+)	686,658 bp
Tssr79666	Chr8:119788783-119788797 (+)	778,318 bp
Tssr79667	Chr8:119813300-119813301 (+)	802,829 bp
Tssr79668	Chr8:119821741-119821771 (+)	811,284 bp
Tssr2700	Chr8:119940640-119940646 (+)	930,171 bp
Tssr79669	Chr8:120004107-120004131 (+)	993,647 bp
Tssr79670	Chr8:120004135-120004167 (+)	993,679 bp
Tssr79671	Chr8:120004168-120004179 (+)	993,702 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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