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Zfp57 Gene Detail
Summary
  • Symbol
    Zfp57
  • Name
    zinc finger protein 57
  • Synonyms
    G19
  • Feature Type
    protein coding gene
  • IDs
    MGI:99204
    NCBI Gene: 22715
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:37312055-37321527 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.16 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99204
 protein coding gene Chr17:37307060-37326196 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023693
 protein coding gene Chr17:37364560-37375345 (+)
A/J MGP_AJ_G0023651
 protein coding gene Chr17:36182803-36192224 (+)
AKR/J MGP_AKRJ_G0023622
 protein coding gene Chr17:36618811-36628169 (+)
BALB/cJ MGP_BALBcJ_G0023658
 protein coding gene Chr17:36426870-36436228 (+)
C3H/HeJ MGP_C3HHeJ_G0023420
 protein coding gene Chr17:37134122-37144487 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024096
 protein coding gene Chr17:38958064-38967615 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021564
 protein coding gene Chr17:33997308-34007398 (+)
CAST/EiJ MGP_CASTEiJ_G0022905
 protein coding gene Chr17:37263504-37274106 (+)
CBA/J MGP_CBAJ_G0023397
 protein coding gene Chr17:40477300-40491671 (+)
DBA/2J MGP_DBA2J_G0023522
 protein coding gene Chr17:35574149-35583673 (+)
FVB/NJ MGP_FVBNJ_G0023495
 protein coding gene Chr17:35181803-35191222 (+)
LP/J MGP_LPJ_G0023600
 protein coding gene Chr17:37892976-37902324 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023518
 protein coding gene Chr17:39266833-39279206 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024141
 protein coding gene Chr17:36962841-36974192 (+)
PWK/PhJ MGP_PWKPhJ_G0022657
 protein coding gene Chr17:34355672-34369125 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022476
 protein coding gene Chr17:35051944-35064428 (+)
WSB/EiJ MGP_WSBEiJ_G0022972
 protein coding gene Chr17:37278032-37290097 (+)



Homology
more
  • Human Ortholog
    ZFP57, ZFP57 zinc finger protein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFP57, ZFP57 zinc finger protein
  • Synonyms
    bA145L22, bA145L22.2, C6orf40, TNDM1, ZNF698
  • Links
    NCBI Gene ID: 346171
    neXtProt AC: NX_Q9NU63
    UniProt: Q9NU63

  • Chr Location
    6p22.1; chr6:29672392-29681155 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit some postnatal lethality with abnormal imprinting and fetal lethality observed in the homozygous offspring of homozygous females.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    904
  • Tissues
    101
  • cDNA Data
    15
  • Literature Summary
    14
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036036 Ensembl Gene Model | MGI Sequence Detail 9473 C57BL/6J ±  kb
transcript ENSMUST00000174524 Ensembl | MGI Sequence Detail 1747 Not Applicable  
polypeptide ENSMUSP00000134418 Ensembl | MGI Sequence Detail 421 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 2
    cDNA 18
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-15901, MGD-MRK-15956
References
more
  • Summaries
    All 56
    Developmental Gene Expression 14
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:17110 Okazaki S, et al., A novel nuclear protein with zinc fingers down-regulated during early mammalian cell differentiation. J Biol Chem. 1994 Mar 4;269(9):6900-7
  • Latest
    J:344097 Zhao J, et al., Maternal and zygotic ZFP57 regulate coronary vascular formation and myocardium maturation in mouse embryo. Dev Dyn. 2024 Jan;253(1):144-156
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory