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Wnt5a Gene Detail
Summary
  • Symbol
    Wnt5a
  • Name
    wingless-type MMTV integration site family, member 5A
  • Synonyms
    8030457G12Rik, Wnt-5a
  • Feature Type
    protein coding gene
  • IDs
    MGI:98958
    NCBI Gene: 22418
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:28226707-28249405 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 16.80 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98958
 protein coding gene Chr14:28224962-28249405 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021095
 protein coding gene Chr14:21543601-21562779 (+)
A/J MGP_AJ_G0021043
 protein coding gene Chr14:20715661-20735129 (+)
AKR/J MGP_AKRJ_G0021020
 protein coding gene Chr14:21790686-21814655 (+)
BALB/cJ MGP_BALBcJ_G0021047
 protein coding gene Chr14:20820543-20844052 (+)
C3H/HeJ MGP_C3HHeJ_G0020830
 protein coding gene Chr14:21654065-21671555 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021479
 protein coding gene Chr14:22424363-22443775 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019042
 protein coding gene Chr14:20830611-20852064 (+)
CAST/EiJ MGP_CASTEiJ_G0020355
 protein coding gene Chr14:21338282-21357895 (+)
CBA/J MGP_CBAJ_G0020797
 protein coding gene Chr14:23308984-23326470 (+)
DBA/2J MGP_DBA2J_G0020919
 protein coding gene Chr14:20792067-20811952 (+)
FVB/NJ MGP_FVBNJ_G0020903
 protein coding gene Chr14:20746459-20767722 (+)
LP/J MGP_LPJ_G0020988
 protein coding gene Chr14:21856726-21875389 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020929
 protein coding gene Chr14:22641293-22663797 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021512
 protein coding gene Chr14:21561351-21579934 (+)
PWK/PhJ MGP_PWKPhJ_G0020103
 protein coding gene Chr14:20208426-20230291 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019927
 protein coding gene Chr14:21102690-21120713 (+)
WSB/EiJ MGP_WSBEiJ_G0020410
 protein coding gene Chr14:21612471-21633922 (+)



Homology
more
  • Human Ortholog
    WNT5A, Wnt family member 5A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WNT5A, Wnt family member 5A
  • Synonyms
    hWNT5A
  • Links
    NCBI Gene ID: 7474
    neXtProt AC: NX_P41221
    UniProt: P41221

  • Chr Location
    3p14.3; chr3:55465715-55505263 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Wnt5a mouse models; 1 with human WNT5A associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    92 phenotypes from 4 alleles in 9 genetic backgrounds
    28 phenotypes from multigenic genotypes
    42 images
    160 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit caudal truncation with shortened anterior-posterior axis, truncation of the snout, tongue and mandible, short fore- and hindlimbs, which lack digits, absent genital tubercle and lung abnormalities. Mutants die perinatally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    309
  • GO References
    75
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2151
  • Tissues
    840
  • cDNA Data
    33
  • Literature Summary
    390
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021994 Ensembl Gene Model | MGI Sequence Detail 22699 C57BL/6J ±  kb
    transcript ENSMUST00000063465 Ensembl | MGI Sequence Detail 7010 Not Applicable  
    polypeptide ENSMUSP00000064878 Ensembl | MGI Sequence Detail 380 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 1
      cDNA 38
      Primer pair 38
      Other 33

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-15443, MGD-MRK-15453, MGI:1924815
    References
    more
    • Summaries
      All 619
      Developmental Gene Expression 390
      Diseases 1
      Gene Ontology 75
      Phenotypes 160
    • Earliest
      J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
    • Latest
      J:346456 Lozovska A, et al., Tgfbr1 controls developmental plasticity between the hindlimb and external genitalia by remodeling their regulatory landscape. Nat Commun. 2024 Mar 20;15(1):2509
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory