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Wnt4 Gene Detail
Summary
  • Symbol
    Wnt4
  • Name
    wingless-type MMTV integration site family, member 4
  • Synonyms
    Wnt-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:98957
    NCBI Gene: 22417
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:137004946-137026812 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 69.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98957
 protein coding gene Chr4:137004800-137027037 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028978
 protein coding gene Chr4:139890234-139912271 (+)
A/J MGP_AJ_G0028937
 protein coding gene Chr4:133942843-133966092 (+)
AKR/J MGP_AKRJ_G0028889
 protein coding gene Chr4:137799459-137822088 (+)
BALB/cJ MGP_BALBcJ_G0028961
 protein coding gene Chr4:134605386-134628637 (+)
C3H/HeJ MGP_C3HHeJ_G0028675
 protein coding gene Chr4:138092142-138115249 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029402
 protein coding gene Chr4:144855201-144877344 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026673
 protein coding gene Chr4:126963270-126985458 (+)
CAST/EiJ MGP_CASTEiJ_G0028107
 protein coding gene Chr4:136246987-136269070 (+)
CBA/J MGP_CBAJ_G0028640
 protein coding gene Chr4:148896451-148921918 (+)
DBA/2J MGP_DBA2J_G0028789
 protein coding gene Chr4:134337587-134362925 (+)
FVB/NJ MGP_FVBNJ_G0028756
 protein coding gene Chr4:133324653-133335496 (+)
LP/J MGP_LPJ_G0028888
 protein coding gene Chr4:139977344-140000639 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028782
 protein coding gene Chr4:153005414-153031406 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029440
 protein coding gene Chr4:138271124-138294674 (+)
PWK/PhJ MGP_PWKPhJ_G0027827
 protein coding gene Chr4:131147275-131169981 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027653
 protein coding gene Chr4:134077335-134101142 (+)
WSB/EiJ MGP_WSBEiJ_G0028185
 protein coding gene Chr4:138443468-138465715 (+)



Homology
more
  • Human Ortholog
    WNT4, Wnt family member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WNT4, Wnt family member 4
  • Synonyms
    SERKAL, WNT-4
  • Links
    NCBI Gene ID: 54361
    neXtProt AC: NX_P56705
    UniProt: P56705

  • Chr Location
    1p36.12; chr1:22117313-22143969 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human WNT4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 10 alleles in 10 genetic backgrounds
    44 phenotypes from multigenic genotypes
    7 images
    122 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit impaired development of the kidney, pituitary gland, and female reproductive system. Mutants die within 24 hours of birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    132
  • GO References
    44
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1992
  • Tissues
    716
  • cDNA Data
    55
  • Literature Summary
    366
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22417 NCBI Gene Model | MGI Sequence Detail 21867 C57BL/6J ±  kb
    transcript NM_009523 RefSeq | MGI Sequence Detail 3823 C57BL/6  
    polypeptide P22724 UniProt | EBI | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 121
      Genomic 1
      cDNA 60
      Primer pair 35
      Other 25

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15442, MGD-MRK-15452
    References
    more
    • Summaries
      All 517
      Developmental Gene Expression 366
      Gene Ontology 44
      Phenotypes 122
    • Earliest
      J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
    • Latest
      J:343800 Souali-Crespo S, et al., Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis. Development. 2023 Dec 15;150(24)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory