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Tac1 Gene Detail
Summary
  • Symbol
    Tac1
  • Name
    tachykinin 1
  • Synonyms
    4930528L02Rik, neurokinin 1, neurokinin A, NK1, NK-1, Nkna, PPTA, PPT-A, preprotachykinin A, SP, substance P
  • Feature Type
    protein coding gene
  • IDs
    MGI:98474
    NCBI Gene: 21333
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:7555061-7562978 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 3.31 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    115 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98474
 protein coding gene Chr6:7554879-7565834 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030443
 protein coding gene Chr6:4451667-4464453 (+)
A/J MGP_AJ_G0030416
 protein coding gene Chr6:4319286-4330242 (+)
AKR/J MGP_AKRJ_G0030343
 protein coding gene Chr6:4469162-4479921 (+)
BALB/cJ MGP_BALBcJ_G0030425
 protein coding gene Chr6:4272093-4283334 (+)
C3H/HeJ MGP_C3HHeJ_G0030139
 protein coding gene Chr6:4362946-4374839 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030880
 protein coding gene Chr6:4590954-4602749 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028091
 protein coding gene Chr6:3863398-3874456 (+)
CAST/EiJ MGP_CASTEiJ_G0029540
 protein coding gene Chr6:4362356-4374291 (+)
CBA/J MGP_CBAJ_G0030117
 protein coding gene Chr6:4711046-4721894 (+)
DBA/2J MGP_DBA2J_G0030261
 protein coding gene Chr6:4261608-4272705 (+)
FVB/NJ MGP_FVBNJ_G0030215
 protein coding gene Chr6:4227451-4238239 (+)
LP/J MGP_LPJ_G0030348
 protein coding gene Chr6:4431600-4442445 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030251
 protein coding gene Chr6:4790548-4805185 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030910
 protein coding gene Chr6:4378560-4389771 (+)
PWK/PhJ MGP_PWKPhJ_G0029255
 protein coding gene Chr6:4149509-4160992 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029091
 protein coding gene Chr6:4403894-4416043 (+)
WSB/EiJ MGP_WSBEiJ_G0029617
 protein coding gene Chr6:4347451-4358589 (+)



Homology
more
  • Human Ortholog
    TAC1, tachykinin precursor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAC1, tachykinin precursor 1
  • Synonyms
    Hs.2563, NK2, NKNA, NPK, TAC2
  • Links
    NCBI Gene ID: 6863
    neXtProt AC: NX_P20366
    UniProt: P20366

  • Chr Location
    7q21.3; chr7:97732084-97740472 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 5 genetic backgrounds
    129 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit absence of agonist-induced hyperalgesia and an impaired response to chemical irritation of the urinary tract. Mice homozygous for a different knock-out allele display hypoalgesia, and reduced anxiety- and depression-related behaviors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    992
  • Tissues
    164
  • cDNA Data
    11
  • Literature Summary
    117
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21333 NCBI Gene Model | MGI Sequence Detail 7918 C57BL/6J ±  kb
    transcript NM_009311 RefSeq | MGI Sequence Detail 1049 ZRU/MplStud  
    polypeptide P41539 UniProt | EBI | MGI Sequence Detail 130 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 14
      Primer pair 4
      Other 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12885, MGD-MRK-14701, MGI:1915432
    References
    more
    • Summaries
      All 313
      Developmental Gene Expression 117
      Gene Ontology 15
      Phenotypes 129
    • Earliest
      J:4891 Bonner TI, et al., The chromosomal location of the two human tackykinin genes: human substance P and neurokinin K. Cytogenet Cell Genet. 1987;46:584 (Abstr.)
    • Latest
      J:346595 Han DS, et al., Involvement of ASIC3 and Substance P in Therapeutic Ultrasound-Mediated Analgesia in Mouse Models of Fibromyalgia. J Pain. 2023 Aug;24(8):1493-1505
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory