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Sox8 Gene Detail
Summary
  • Symbol
    Sox8
  • Name
    SRY (sex determining region Y)-box 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:98370
    NCBI Gene: 20681
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25784865-25789666 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.69 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98370
 protein coding gene Chr17:25784634-25789726 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023358
 protein coding gene Chr17:24646333-24651098 (-)
A/J MGP_AJ_G0023317
 protein coding gene Chr17:23937331-23942118 (-)
AKR/J MGP_AKRJ_G0023283
 protein coding gene Chr17:24039993-24044779 (-)
BALB/cJ MGP_BALBcJ_G0023322
 protein coding gene Chr17:24161125-24165910 (-)
C3H/HeJ MGP_C3HHeJ_G0023082
 protein coding gene Chr17:24418936-24423706 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023764
 protein coding gene Chr17:25704127-25708899 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021240
 protein coding gene Chr17:21403343-21408118 (-)
CAST/EiJ MGP_CASTEiJ_G0022584
 protein coding gene Chr17:24291838-24296612 (-)
CBA/J MGP_CBAJ_G0023057
 protein coding gene Chr17:26596757-26601542 (-)
DBA/2J MGP_DBA2J_G0023187
 protein coding gene Chr17:23536004-23540805 (-)
FVB/NJ MGP_FVBNJ_G0023157
 protein coding gene Chr17:23257237-23262428 (-)
LP/J MGP_LPJ_G0023264
 protein coding gene Chr17:24938399-24943175 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023176
 protein coding gene Chr17:26227688-26232482 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023804
 protein coding gene Chr17:24340362-24345158 (-)
PWK/PhJ MGP_PWKPhJ_G0022333
 protein coding gene Chr17:22291766-22296590 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022151
 protein coding gene Chr17:22420059-22424841 (-)
WSB/EiJ MGP_WSBEiJ_G0022647
 protein coding gene Chr17:24406020-24410791 (-)



Homology
more
  • Human Ortholog
    SOX8, SRY-box transcription factor 8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOX8, SRY-box transcription factor 8
  • Links
    NCBI Gene ID: 30812
    neXtProt AC: NX_P57073
    UniProt: P57073

  • Chr Location
    16p13.3; chr16:981444-986979 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit a 30% decrease in adult body weight due to diminished fat stores, and a reduction of several tarsals which subsequently fail to fuse.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    72
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1633
  • Tissues
    323
  • cDNA Data
    34
  • Literature Summary
    69
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20681 NCBI Gene Model | MGI Sequence Detail 4802 C57BL/6J ±  kb
    transcript NM_011447 RefSeq | MGI Sequence Detail 2999 ZRU/MplStud  
    polypeptide Q04886 UniProt | EBI | MGI Sequence Detail 464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 35
      Primer pair 11
      Other 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-14509
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 69
      Gene Ontology 23
      Phenotypes 35
    • Earliest
      J:4011 Wright EM, et al., Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993 Feb 11;21(3):744
    • Latest
      J:343800 Souali-Crespo S, et al., Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis. Development. 2023 Dec 15;150(24)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory