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Sstr1 Gene Detail
Summary
  • Symbol
    Sstr1
  • Name
    somatostatin receptor 1
  • Synonyms
    Smstr1, Smstr-1, sst1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98327
    NCBI Gene: 20605
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:58258558-58260673 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 25.61 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98327
 protein coding gene Chr12:58258524-58262822 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019763
 protein coding gene Chr12:57399083-57401751 (+)
A/J MGP_AJ_G0019722
 protein coding gene Chr12:55294017-55296686 (+)
AKR/J MGP_AKRJ_G0019697
 protein coding gene Chr12:57057332-57060000 (+)
BALB/cJ MGP_BALBcJ_G0019702
 protein coding gene Chr12:55659302-55661972 (+)
C3H/HeJ MGP_C3HHeJ_G0019507
 protein coding gene Chr12:57134553-57137224 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020154
 protein coding gene Chr12:59098572-59101237 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017774
 protein coding gene Chr12:53709234-53711974 (+)
CAST/EiJ MGP_CASTEiJ_G0019059
 protein coding gene Chr12:52050779-52055046 (+)
CBA/J MGP_CBAJ_G0019476
 protein coding gene Chr12:61212710-61215379 (+)
DBA/2J MGP_DBA2J_G0019592
 protein coding gene Chr12:55201166-55203835 (+)
FVB/NJ MGP_FVBNJ_G0019580
 protein coding gene Chr12:54478550-54481486 (+)
LP/J MGP_LPJ_G0019664
 protein coding gene Chr12:57393719-57396213 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019618
 protein coding gene Chr12:62809037-62811706 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020188
 protein coding gene Chr12:56506548-56509217 (+)
PWK/PhJ MGP_PWKPhJ_G0018826
 protein coding gene Chr12:49592819-49597185 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018619
 protein coding gene Chr12:50912690-50916983 (+)
WSB/EiJ MGP_WSBEiJ_G0019110
 protein coding gene Chr12:57063364-57066035 (+)



Homology
more
  • Human Ortholog
    SSTR1, somatostatin receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SSTR1, somatostatin receptor 1
  • Synonyms
    SRIF-2, SS1R, SS-1-R, SS1-R, SST1
  • Links
    NCBI Gene ID: 6751
    neXtProt AC: NX_P30872
    UniProt: P30872

  • Chr Location
    14q21.1; chr14:38207904-38213067 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 4 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display abnormal eye electrophysiology. Mice homozygous for a second targeted mutation display hypoactivity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    988
  • Tissues
    108
  • cDNA Data
    6
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035431 Ensembl Gene Model | MGI Sequence Detail 2116 C57BL/6J ±  kb
    transcript ENSMUST00000110671 Ensembl | MGI Sequence Detail 1752 Not Applicable  
    polypeptide ENSMUSP00000106299 Ensembl | MGI Sequence Detail 391 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 4
      cDNA 6
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14454, MGD-MRK-14457
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 24
    • Earliest
      J:2346 Yamada Y, et al., Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):251-5
    • Latest
      J:305429 Kaiser M, et al., Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory