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Sst Gene Detail
Summary
  • Symbol
    Sst
  • Name
    somatostatin
  • Synonyms
    preprosomatostatin, Smst, SOM, SRIF
  • Feature Type
    protein coding gene
  • IDs
    MGI:98326
    NCBI Gene: 20604
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:23708323-23709708 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 15.00 cM, cytoband cen-C3
  • Mapping Data
    39 experiments
Strain
Comparison
more
  • SNPs within 2kb
    28 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98326
protein coding gene Chr16:23708323-23710041 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022686
protein coding gene Chr16:21488504-21489767 (-)
A/J MGP_AJ_G0022648
protein coding gene Chr16:20475171-20476434 (-)
AKR/J MGP_AKRJ_G0022622
protein coding gene Chr16:21341167-21342430 (-)
BALB/cJ MGP_BALBcJ_G0022653
protein coding gene Chr16:20670122-20671385 (-)
C3H/HeJ MGP_C3HHeJ_G0022417
protein coding gene Chr16:21461273-21462536 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023102
protein coding gene Chr16:22025302-22026565 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020620
protein coding gene Chr16:21111301-21112563 (-)
CAST/EiJ MGP_CASTEiJ_G0021946
protein coding gene Chr16:21461337-21462599 (-)
CBA/J MGP_CBAJ_G0022388
protein coding gene Chr16:22930526-22931789 (-)
DBA/2J MGP_DBA2J_G0022520
protein coding gene Chr16:20435941-20437204 (-)
FVB/NJ MGP_FVBNJ_G0022496
protein coding gene Chr16:20429723-20430986 (-)
LP/J MGP_LPJ_G0022588
protein coding gene Chr16:21292586-21293849 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022515
protein coding gene Chr16:22410711-22411974 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023114
protein coding gene Chr16:21297389-21298652 (-)
PWK/PhJ MGP_PWKPhJ_G0021685
protein coding gene Chr16:20708543-20709805 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021516
protein coding gene Chr16:21032322-21033583 (-)
WSB/EiJ MGP_WSBEiJ_G0021990
protein coding gene Chr16:21252722-21253984 (-)



Homology
more
  • Human Ortholog
    SST, somatostatin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SST, somatostatin
  • Synonyms
    SMST, SST1
  • Links
    NCBI Gene ID: 6750
    neXtProt AC: NX_P61278
    UniProt: P61278

  • Chr Location
    3q27.3; chr3:187668912-187670394 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 6 alleles in 8 genetic backgrounds
    9 phenotypes from multigenic genotypes
    514 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show altered GH secretory dynamics, hypergastremia, and reduced hippocampal bursting and excitatory transmission. Mice homozygous for another null allele show impaired motor learning, higher GH and corticosterone levels,gastric fundus hyperplasia and hyperacidity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004366 Ensembl Gene Model | MGI Sequence Detail 1386 C57BL/6J ±  kb
    transcript ENSMUST00000004480 Ensembl | MGI Sequence Detail 721 Not Applicable  
    polypeptide ENSMUSP00000004480 Ensembl | MGI Sequence Detail 116 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      Genomic 7
      cDNA 41
      Primer pair 15
      Other 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14453
    References
    more
    • Summaries
      All 1100
      Developmental Gene Expression 502
      Gene Ontology 9
      Phenotypes 514
    • Earliest
      J:7362 Shen LP, et al., Sequence of the human somatostatin I gene. Science. 1984 Apr 13;224(4645):168-71
    • Latest
      J:344464 Rothe J, et al., The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet development. Commun Biol. 2024 Jan 16;7(1):104

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory