Epha4 MGI Mouse Gene Detail - MGI:98277

Symbol

Epha4
Name

Eph receptor A4
Synonyms

2900005C20Rik, Cek8, Hek8, rb, Sek, Sek1, Tyro1

Feature Type

protein coding gene
IDs

MGI:98277
NCBI Gene: 13838
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:77343822-77491725 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 39.55 cM, cytoband C1-C5
Mapping Data

5 experiments

SNPs within 2kb

825 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98277	protein coding gene	Chr1:77343819-77491763 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016195	protein coding gene	Chr1:78038489-78189818 (-)
A/J	MGP_AJ_G0016178	protein coding gene	Chr1:75309807-75455170 (-)
AKR/J	MGP_AKRJ_G0016135	protein coding gene	Chr1:77364281-77514407 (-)
BALB/cJ	MGP_BALBcJ_G0016133	protein coding gene	Chr1:75390459-75541518 (-)
C3H/HeJ	MGP_C3HHeJ_G0015964	protein coding gene	Chr1:77721334-77865659 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016586	protein coding gene	Chr1:81053366-81213081 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014307	protein coding gene	Chr1:70779309-70925699 (-)
CAST/EiJ	MGP_CASTEiJ_G0015548	protein coding gene	Chr1:77099829-77250640 (-)
CBA/J	MGP_CBAJ_G0015937	protein coding gene	Chr1:83702766-83854333 (-)
DBA/2J	MGP_DBA2J_G0016038	protein coding gene	Chr1:74623209-74764726 (-)
FVB/NJ	MGP_FVBNJ_G0016041	protein coding gene	Chr1:73804516-73946527 (-)
LP/J	MGP_LPJ_G0016110	protein coding gene	Chr1:79173425-79318852 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016061	protein coding gene	Chr1:86997533-87151351 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016633	protein coding gene	Chr1:77491370-77643454 (-)
PWK/PhJ	MGP_PWKPhJ_G0015335	protein coding gene	Chr1:74090948-74236985 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015113	protein coding gene	Chr1:76817810-76976856 (-)
WSB/EiJ	MGP_WSBEiJ_G0015610	protein coding gene	Chr1:77282343-77430531 (-)

Human Ortholog

EPHA4, EPH receptor A4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EPHA4, EPH receptor A4
Synonyms

EK8, HEK8, SEK, TYRO1
Links

HGNC:3388

NCBI Gene ID: 2043

neXtProt AC: NX_P54764

UniProt: P54764
Chr Location

2q36.1; chr2:221418027-221574202 (-) GRCh38

MGI Vertebrate Homology

Epha4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: EPHA4
Protein SuperFamily

TyrPK_ephrin_receptor
Gene Tree

Epha4

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Phenotype Summary

37 phenotypes from 14 alleles in 21 genetic backgrounds
15 phenotypes from multigenic genotypes
2 images
117 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

75
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

52
Radiation induced

1
Spontaneous

2
Targeted

17
Genomic Mutations

2 involving Epha4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

66 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations show loss of limb alternation in locomotion and axon guidance defects of the corticospinal tract within medulla and spinal cord, resulting in aberrant midline projections resulting in a hopping gait. Heterozygotes show a less severe phenotype.

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All GO Annotations

127
GO References

27

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1806
Tissues

570
cDNA Data

43
Literature Summary

226

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA EPHA4

Xenbase epha4

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All Sequences

60
RefSeq

8
UniProt

6
CCDS

CCDS35627.1

Ensembl

ENSMUSG00000026235 (Evidence)
NCBI Gene

13838

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026235	Ensembl Gene Model \| MGI Sequence Detail	147904	C57BL/6J	± kb
transcript	ENSMUST00000027451	Ensembl \| MGI Sequence Detail	6328	Not Applicable
polypeptide	ENSMUSP00000027451	Ensembl \| MGI Sequence Detail	986	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007124 ephrin type-A receptor 4

(term hierarchy)
PDB

1B0X, 2HEL, 2XYU, 2Y6M, 2Y6O
EC

2.7.10.1
InterPro Domains

IPR001090 Ephrin receptor ligand binding domain

IPR027936 Ephrin receptor, transmembrane domain

IPR016257 Ephrin receptor type-A /type-B

IPR034270 Ephrin type-A receptor 4, ligand binding domain

IPR030602 Ephrin type-A receptor 4, SAM domain

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR008979 Galactose-binding-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like

IPR001426 Tyrosine-protein kinase, receptor class V, conserved site

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All nucleic 78

cDNA 50

Primer pair 6

Other 22

Microarray probesets 8

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MGD-MRK-14356, MGD-MRK-38166, MGI:109122, MGI:1920161, MGI:2138218

Summaries

All 384

Developmental Gene Expression 226

Gene Ontology 27

Phenotypes 117
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:346126 Pappas MP, et al., Sall4 regulates posterior trunk mesoderm development by promoting mesodermal gene expression and repressing neural genes in the mesoderm. Development. 2024 Mar 1;151(5)

TSS for Epha4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr12418	Chr1:77491685-77491739 (-)	13 bp
Tssr12417	Chr1:77465334-77465338 (-)	26,389 bp
Tssr12416	Chr1:77433901-77433909 (-)	57,820 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23