| Human Disease | Mouse Models | ||||
|---|---|---|---|---|---|
|
IDs
|
early conceptus |
embryo ectoderm |
embryo endoderm |
embryo mesoderm |
embryo mesenchyme |
extraembryonic component |
alimentary system |
auditory system |
branchial arches |
cardiovascular system |
connective tissue |
endocrine system |
exocrine system |
hemolymphoid system |
integumental system |
limbs |
liver and biliary system |
musculoskeletal system |
nervous system |
olfactory system |
reproductive system |
respiratory system |
urinary system |
visual system |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Transcription Start Site | Location | Distance from Gene 5'-end |
| Tssr42212 | Chr4:78130186-78130236 (-) | -13 bp |
| Tssr42211 | Chr4:78130064-78130126 (-) | 103 bp |
| Tssr42210 | Chr4:78129995-78130027 (-) | 187 bp |
| Tssr42209 | Chr4:78129969-78129991 (-) | 218 bp |
| Tssr42208 | Chr4:78129922-78129933 (-) | 270 bp |
| Tssr42207 | Chr4:78099126-78099129 (-) | 31,070 bp |
| Tssr1209 | Chr4:78010445-78010449 (-) | 119,751 bp |
| Tssr42206 | Chr4:77996671-77996691 (-) | 133,517 bp |
| Tssr42205 | Chr4:77987721-77987733 (-) | 142,471 bp |
| Tssr42204 | Chr4:77978650-77978655 (-) | 151,545 bp |
| Tssr42203 | Chr4:77967133-77967144 (-) | 163,059 bp |
| Tssr42202 | Chr4:77962048-77962057 (-) | 168,145 bp |
| Tssr42201 | Chr4:77921820-77921823 (-) | 208,376 bp |
| Tssr42200 | Chr4:77834261-77834285 (-) | 295,925 bp |
| Tssr42199 | Chr4:77823255-77823268 (-) | 306,936 bp |
| Tssr42198 | Chr4:77811634-77811638 (-) | 318,562 bp |
| Tssr42197 | Chr4:77809935-77809936 (-) | 320,262 bp |
| Tssr42196 | Chr4:77775013-77775019 (-) | 355,182 bp |
| Tssr42195 | Chr4:77744483-77744497 (-) | 385,708 bp |
| Tssr42194 | Chr4:77741801-77741804 (-) | 388,395 bp |
| Tssr42193 | Chr4:77741154-77741156 (-) | 389,043 bp |
| Tssr42192 | Chr4:77706804-77706808 (-) | 423,392 bp |
| Tssr42191 | Chr4:77705400-77705415 (-) | 424,790 bp |
| Tssr42190 | Chr4:77702988-77703014 (-) | 427,197 bp |
| Tssr42189 | Chr4:77693565-77693570 (-) | 436,630 bp |
| Tssr42188 | Chr4:77682612-77682616 (-) | 447,584 bp |
| Tssr42187 | Chr4:77619310-77619337 (-) | 510,874 bp |
| Tssr42186 | Chr4:77444199-77444203 (-) | 685,997 bp |
| Tssr42185 | Chr4:77372413-77372421 (-) | 757,781 bp |
| Tssr42184 | Chr4:77372346-77372357 (-) | 757,846 bp |
| Tssr42183 | Chr4:77345223-77345225 (-) | 784,974 bp |
| Tssr42182 | Chr4:77087059-77087073 (-) | 1,043,132 bp |
| Tssr42181 | Chr4:77086985-77087020 (-) | 1,043,195 bp |
| Tssr42180 | Chr4:77072978-77072987 (-) | 1,057,215 bp |
| Tssr42179 | Chr4:77072842-77072855 (-) | 1,057,349 bp |
| Tssr42178 | Chr4:77070198-77070211 (-) | 1,059,993 bp |
| Tssr42177 | Chr4:77056067-77056068 (-) | 1,074,130 bp |
| Tssr42175 | Chr4:76832943-76832992 (-) | 1,297,230 bp |
| Tssr42174 | Chr4:76795810-76795813 (-) | 1,334,386 bp |
| Tssr1207 | Chr4:76782417-76782423 (-) | 1,347,778 bp |
| Tssr42173 | Chr4:76772720-76772722 (-) | 1,357,477 bp |
| Tssr42172 | Chr4:76772553-76772557 (-) | 1,357,643 bp |
| Tssr42171 | Chr4:76718912-76718918 (-) | 1,411,283 bp |
| Tssr42170 | Chr4:76666465-76666481 (-) | 1,463,725 bp |
| Tssr42169 | Chr4:76488584-76488588 (-) | 1,641,612 bp |
| Tssr42168 | Chr4:76477284-76477308 (-) | 1,652,902 bp |
| Tssr42167 | Chr4:76475274-76475277 (-) | 1,654,922 bp |
| Tssr42166 | Chr4:76454648-76454652 (-) | 1,675,548 bp |
| Tssr42165 | Chr4:76405593-76405604 (-) | 1,724,599 bp |
| Tssr42164 | Chr4:76368827-76368852 (-) | 1,761,358 bp |
| Tssr42163 | Chr4:76368715-76368733 (-) | 1,761,474 bp |
| Tssr42162 | Chr4:76368005-76368022 (-) | 1,762,184 bp |
| Tssr42161 | Chr4:76354100-76354115 (-) | 1,776,090 bp |
| Tssr42160 | Chr4:76354029-76354033 (-) | 1,776,167 bp |
| Tssr42159 | Chr4:76276468-76276471 (-) | 1,853,728 bp |
| Tssr42158 | Chr4:76262464-76262487 (-) | 1,867,722 bp |
| Tssr42157 | Chr4:76262399-76262458 (-) | 1,867,769 bp |
| Tssr42156 | Chr4:76250702-76250704 (-) | 1,879,495 bp |
| Tssr42155 | Chr4:76140796-76140803 (-) | 1,989,398 bp |
| Tssr42154 | Chr4:76060312-76060323 (-) | 2,069,880 bp |
| Tssr42153 | Chr4:76022593-76022605 (-) | 2,107,599 bp |
| Tssr42152 | Chr4:76021081-76021086 (-) | 2,109,114 bp |
| Tssr42151 | Chr4:75901002-75901025 (-) | 2,229,184 bp |
| QTL | Genetic Location* | Genome Location (GRCm39) | Reference | QTL Note |
| Papg1 | Chr4, 47.21 cM | Chr4:102781167-102781279 | J:78525 | Microarray gene expression analysis was used to identify candidate genes for tumor resistant and tumor susceptibility QTLs Par8,2,3,4 and and Pas1-4, respectively. Transcripts found within the flanking markers of each QTL were identified and matched to transcripts from Affymetrix probe sets. RNA from A/J, BALB/cJ, C57BL/6J, and SM/J were used for analysis. Pas1 is located between 48.2 cM and 75 cM on mouse Chromosome 6 and was identified in a cross between A/J and C57BL/6J. Candidate oncogenic genes identified by microarray analysis are hes related protein (**Note- this gene is not found in MGD), Ppih (cyclophilin H **Note-this gene is positioned on mouse Chromosome 4 in MGD), Ptpro, Mglap, Recql, and Bcat1 (ECA39). Other candidate genes identified via differential expression are Ccnd2 (cyclin D2) and high mobility group protein 2A,4 (**Note-this gene is not found in MGD). K-ras, a positional candidate gene, did not show significantly different expression between A/J and C57BL/6J. Pas2 is located between 17 cMand 23.2 cM on mouse Chromosome 17 and was identified in crosses involving A/J and C57BL/6J. Candidate oncogenic genes identified by microarray analysis are Notch4, Hnrpk (**Note-this gene is positioned on mouse Chromosome 13 in MGD), and Enpp4. Other candidate genes identified via differential expression are Cdc5l, Tapbp (tapasin), H2-Ke2, Rbx1 (regulator of cullins 1 **Note- this gene is found on mouse Chromosome 15 in MGD), Psors1c2, H2-Ke6, and H2-M9. Positional candidate genes Tnf (Tnfa) and Lta (Tnfb) did not show significantly different expression between A/J and C57BL/6J. Pas3 is located between 2 cM and 25 cM on mouse Chromosome 19 and was identified in a cross between A/J and C57BL/6J. Candidate oncogenic genes identified by microarray analysis are golgi specific Gbf1 (brefeldin A resistance factor 1) and Sema4g. Other candidate genes identified via differential expression are Pdcd4, Adrb1, and Cdc25l. Pas4 is located between 42 cM and 72 cM on mouse Chromosome 9 and was identified in a cross between A/J and C57BL/6J. Candidate oncogenic genes identified by microarray analysis are Nck1, Pthr1, and Topbp1. Candidate tumor suppressor genes for Pas4 are G protein alpha I 2 (**Note-this gene is not found in MGD), Cdk5 (**Note-this gene is positioned on mouse Chromosome 5 in MGD), Smarcd3 (**Note-this gene is positioned on mouse Chromosome 5 in MGD), and Nckipsd. Another candidate gene identified via differential expression is Stag1. Par1 is located between 37 cM and 59 cM on mouse Chromosome 11 and was identified in a cross between A/J and SM/J. Candidate oncogenic genes identified by microarray analysis are Alox12 (12-lipoxygenase), Zfp617 (zinc finger protein s11-6), Grn, and Rpl29 (**Note-this gene is positioned on mouse Chromosome 9 in MGD). A tumor suppressor candidate gene for Par1 is Spop. 02.05.2016 Curator Note: Becasue Par1 was originally mapped in J:32079 using an (A/J x M. spretus) x C57BL/6J interspecific backcross, which differs from the cross used here, we have equated this QTL with Par8 which was mapped using A/J and SM/J mice, see J:41849. Par2 is located between 32 cM and 57 cM on mouse Chromosome 18 and was identified in a cross between A/J and BALB/cJ. Candidate oncogenic genes identified by microarray analysis are Adrb2, Mbd2, Htr4, Hmgb1-rs12, and Iigp1. Dcc is an expected candidate gene of Par2 but its expression pattern (A/J=high expression) is not consistent with its effect on tumor resistance/susceptibility. Mc2r is another candidate gene identified via differential gene expression between A/J and SM/J. Par3 is located between 13 cM and 44 cM on mouse Chromosome 12 and was identified in a cross between A/J and SM/J. Only one candidate oncogenic gene was identified for Par3. This is placental growth factor, Pgf. Par4 is located between 10.6 cM and 42.5 cM on mouse Chromosome 4 and was identified in a cross between A/J and BALB/cJ. Candidate tumor suppressor genes identified via differential gene expression are Cdkn2a, Egfl5, Ambp (bikunin), Pole3, Tyrp1, Ifnab, and Igfbpl1.Candidate oncogenes are T complex protein 1 alpha (**Note-this gene is not found in MGD) and Stmn1. Another candidate gene identified via differential expression between A/J and SM/J is Ptprd. |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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