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Pgr Gene Detail
Summary
  • Symbol
    Pgr
  • Name
    progesterone receptor
  • Synonyms
    9930019P03Rik, ENSMUSG00000074510, NR3C3, PR, PR-A, PR-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:97567
    NCBI Gene: 18667
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:8899834-8968612 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    492 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97567
 protein coding gene Chr9:8890017-8968612 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034336
 protein coding gene Chr9:5771465-5841866 (+)
A/J MGP_AJ_G0034314
 protein coding gene Chr9:5904557-5976150 (+)
AKR/J MGP_AKRJ_G0034242
 protein coding gene Chr9:5722665-5793688 (+)
BALB/cJ MGP_BALBcJ_G0034308
 protein coding gene Chr9:5615211-5683807 (+)
C3H/HeJ MGP_C3HHeJ_G0034019
 protein coding gene Chr9:5960568-6034186 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034830
 protein coding gene Chr9:5979458-6053361 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031768
 protein coding gene Chr9:5028358-5095638 (+)
CAST/EiJ MGP_CASTEiJ_G0033347
 protein coding gene Chr9:5896258-5968804 (+)
CBA/J MGP_CBAJ_G0033992
 protein coding gene Chr9:6230540-6311129 (+)
DBA/2J MGP_DBA2J_G0034149
 protein coding gene Chr9:5748934-5820994 (+)
FVB/NJ MGP_FVBNJ_G0034094
 protein coding gene Chr9:5489469-5558171 (+)
LP/J MGP_LPJ_G0034235
 protein coding gene Chr9:5785691-5856397 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034138
 protein coding gene Chr9:6912063-6984656 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034849
 protein coding gene Chr9:5737221-5807397 (+)
PWK/PhJ MGP_PWKPhJ_G0033050
 protein coding gene Chr9:5814749-5888033 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032888
 protein coding gene Chr9:5930149-6003059 (+)
WSB/EiJ MGP_WSBEiJ_G0033462
 protein coding gene Chr9:5726283-5797863 (+)



Homology
more
  • Human Ortholog
    PGR, progesterone receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGR, progesterone receptor
  • Synonyms
    NR3C3, PR
  • Links
    NCBI Gene ID: 5241
    neXtProt AC: NX_P06401
    UniProt: P06401

  • Chr Location
    11q22.1; chr11:101029624-101129813 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human PGR associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 10 alleles in 10 genetic backgrounds
    83 phenotypes from multigenic genotypes
    3 images
    327 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null female mice are sterile and exhibit ovulatory defects, uterine hyperplasia, and impaired mammary development. Females lacking only isoform A are infertile but show normal mammary development, while females lacking only isoform B are fertile but present with mammary developmental defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    857
  • Tissues
    107
  • cDNA Data
    18
  • Literature Summary
    51
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031870 Ensembl Gene Model | MGI Sequence Detail 68779 C57BL/6J ±  kb
    transcript ENSMUST00000070463 Ensembl | MGI Sequence Detail 3068 Not Applicable  
    polypeptide ENSMUSP00000063562 Ensembl | MGI Sequence Detail 926 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 5
      cDNA 18
      Primer pair 5
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13282, MGI:2143361, MGI:2444097, MGI:3642750
    References
    more
    • Summaries
      All 449
      Developmental Gene Expression 51
      Diseases 6
      Gene Ontology 18
      Phenotypes 327
    • Earliest
      J:12501 Naylor SL, et al., The progesterone receptor gene is on mouse Chromosome 9. Cytogenet Cell Genet. 1989;51:1051 (Abstr.)
    • Latest
      J:345641 Zhang D, et al., CK1alpha deficiency impairs mouse uterine adenogenesis by inducing epithelial cell apoptosis through GSK3beta pathway and inhibiting Foxa2 expression through p53 pathway. Biol Reprod. 2024 Feb 10;110(2):246-260
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory