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Pfn2 Gene Detail
Summary
  • Symbol
    Pfn2
  • Name
    profilin 2
  • Synonyms
    Pfn
  • Feature Type
    protein coding gene
  • IDs
    MGI:97550
    NCBI Gene: 18645
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:57749316-57755178 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 28.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    16 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97550
 protein coding gene Chr3:57749316-57755500 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027233
 protein coding gene Chr3:56637686-56643870 (-)
A/J MGP_AJ_G0027193
 protein coding gene Chr3:54897599-54903781 (-)
AKR/J MGP_AKRJ_G0027163
 protein coding gene Chr3:56023979-56030163 (-)
BALB/cJ MGP_BALBcJ_G0027206
 protein coding gene Chr3:54716752-54722936 (-)
C3H/HeJ MGP_C3HHeJ_G0026949
 protein coding gene Chr3:56235195-56241379 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027652
 protein coding gene Chr3:58747505-58753689 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0026401
 protein coding gene Chr3:56400914-56407102 (-)
CBA/J MGP_CBAJ_G0026925
 protein coding gene Chr3:60693579-60699763 (-)
DBA/2J MGP_DBA2J_G0027059
 protein coding gene Chr3:54397232-54403414 (-)
FVB/NJ MGP_FVBNJ_G0027027
 protein coding gene Chr3:53365794-53371980 (-)
LP/J MGP_LPJ_G0027171
 protein coding gene Chr3:57398821-57405005 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027045
 protein coding gene Chr3:64804804-64810988 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027710
 protein coding gene Chr3:55980751-55986935 (-)
PWK/PhJ MGP_PWKPhJ_G0026133
 protein coding gene Chr3:54043650-54049830 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025946
 protein coding gene Chr3:55650099-55654482 (-)
WSB/EiJ MGP_WSBEiJ_G0026475
 protein coding gene Chr3:56055965-56062149 (-)



Homology
more
  • Human Ortholog
    PFN2, profilin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PFN2, profilin 2
  • Synonyms
    D3S1319E, PFL
  • Links
    NCBI Gene ID: 5217
    neXtProt AC: NX_P35080
    UniProt: P35080

  • Chr Location
    3q25.1; chr3:149964904-150050788 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display increased synaptic excitability of neocortical glutamatergic neurons due to higher vesicle exocytosis, hyperactivation of the striatum, hyperactivity, and increased novelty-seeking behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    803
  • Tissues
    33
  • cDNA Data
    86
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18645 NCBI Gene Model | MGI Sequence Detail 5863 C57BL/6J ±  kb
    transcript NM_019410 RefSeq | MGI Sequence Detail 2020 ZRU/MplStud  
    polypeptide Q9JJV2 UniProt | EBI | MGI Sequence Detail 140 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 89
      cDNA 87
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13248, MGD-MRK-13250
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 12
      Phenotypes 7
    • Earliest
      J:9773 Widada JS, et al., Total coding sequence of profilin cDNA from Mus musculus macrophage. Nucleic Acids Res. 1989 Apr 11;17(7):2855
    • Latest
      J:310888 Di Domenico M, et al., Specificity and Redundancy of Profilin 1 and 2 Function in Brain Development and Neuronal Structure. Cells. 2021 Sep 3;10(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory