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Pdgfb Gene Detail
Summary
  • Symbol
    Pdgfb
  • Name
    platelet derived growth factor, B polypeptide
  • Synonyms
    PDGF-B, Sis
  • Feature Type
    protein coding gene
  • IDs
    MGI:97528
    NCBI Gene: 18591
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79880075-79899178 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.85 cM, cytoband E
  • Mapping Data
    56 experiments
Strain
Comparison
more
  • SNPs within 2kb
    216 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    3
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97528
 protein coding gene Chr15:79880066-79899178 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022091
 protein coding gene Chr15:80295327-80315763 (-)
A/J MGP_AJ_G0022052
 protein coding gene Chr15:77520616-77539516 (-)
AKR/J MGP_AKRJ_G0022027
 protein coding gene Chr15:79689126-79708036 (-)
BALB/cJ MGP_BALBcJ_G0022058
 protein coding gene Chr15:77530067-77548995 (-)
C3H/HeJ MGP_C3HHeJ_G0021829
 protein coding gene Chr15:79675992-79696301 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022501
 protein coding gene Chr15:83458721-83477606 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020031
 protein coding gene Chr15:74006347-74025554 (-)
CAST/EiJ MGP_CASTEiJ_G0021350
 protein coding gene Chr15:80397096-80415933 (-)
CBA/J MGP_CBAJ_G0021794
 protein coding gene Chr15:86077573-86096499 (-)
DBA/2J MGP_DBA2J_G0021923
 protein coding gene Chr15:77018483-77037437 (-)
FVB/NJ MGP_FVBNJ_G0021901
 protein coding gene Chr15:76040025-76059036 (-)
LP/J MGP_LPJ_G0021991
 protein coding gene Chr15:80475689-80496833 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021921
 protein coding gene Chr15:91135503-91155587 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022515
 protein coding gene Chr15:79720393-79739277 (-)
PWK/PhJ MGP_PWKPhJ_G0021092
 protein coding gene Chr15:77020704-77040418 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020929
 protein coding gene Chr15:79523722-79542520 (-)
WSB/EiJ MGP_WSBEiJ_G0021402
 protein coding gene Chr15:80116094-80135262 (-)



Homology
more
  • Human Ortholog
    PDGFB, platelet derived growth factor subunit B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDGFB, platelet derived growth factor subunit B
  • Synonyms
    c-sis, IBGC5, PDGF2, PDGF-2, SIS, SSV
  • Links
    NCBI Gene ID: 5155
    neXtProt AC: NX_P01127
    UniProt: P01127

  • Chr Location
    22q13.1; chr22:39223359-39244982 (-)  GRCh38
Human Diseases
more
  • Diseases
    7 with human PDGFB associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    65 phenotypes from 3 alleles in 6 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit absence of microvascular pericytes, capillary aneurisms, endothelial hyperplasia, edema, hemorrhages, erythroblastosis, macrocytic anemia, thrombocytopenia, kidney defects, and perinatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    171
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    901
  • Tissues
    111
  • cDNA Data
    26
  • Literature Summary
    89
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000489 Ensembl Gene Model | MGI Sequence Detail 19104 C57BL/6J ±  kb
    transcript ENSMUST00000000500 Ensembl | MGI Sequence Detail 2944 Not Applicable  
    polypeptide ENSMUSP00000000500 Ensembl | MGI Sequence Detail 241 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 12
      cDNA 27
      Primer pair 9
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13212, MGD-MRK-14423
    References
    more
    • Summaries
      All 309
      Developmental Gene Expression 89
      Diseases 1
      Gene Ontology 22
      Phenotypes 76
    • Earliest
      J:6890 Dalla-Favera R, et al., Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene. Science. 1982 Nov 12;218(4573):686-8
    • Latest
      J:343519 Weng Y, et al., An integral blood-brain barrier in adulthood relies on microglia-derived PDGFB. Brain Behav Immun. 2024 Jan;115:705-717
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory