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Pde6g Gene Detail
Summary
  • Symbol
    Pde6g
  • Name
    phosphodiesterase 6G, cGMP-specific, rod, gamma
  • Synonyms
    Pdeg
  • Feature Type
    protein coding gene
  • IDs
    MGI:97526
    NCBI Gene: 18588
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120338433-120344326 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 84.14 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97526
 protein coding gene Chr11:120338431-120344326 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019500
 protein coding gene Chr11:124913982-124919671 (-)
A/J MGP_AJ_G0019468
 protein coding gene Chr11:119355883-119361812 (-)
AKR/J MGP_AKRJ_G0019438
 protein coding gene Chr11:122943413-122951091 (-)
BALB/cJ MGP_BALBcJ_G0019443
 protein coding gene Chr11:119709991-119716357 (-)
C3H/HeJ MGP_C3HHeJ_G0019249
 protein coding gene Chr11:123280960-123287776 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019891
 protein coding gene Chr11:128692021-128699233 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017517
 protein coding gene Chr11:116345036-116350521 (-)
CAST/EiJ MGP_CASTEiJ_G0018803
 protein coding gene Chr11:124766915-124774283 (-)
CBA/J MGP_CBAJ_G0019220
 protein coding gene Chr11:133726972-133735109 (-)
DBA/2J MGP_DBA2J_G0019332
 protein coding gene Chr11:118724620-118730705 (-)
FVB/NJ MGP_FVBNJ_G0019324
 protein coding gene Chr11:118434110-118440004 (-)
LP/J MGP_LPJ_G0019404
 protein coding gene Chr11:125211939-125218207 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019357
 protein coding gene Chr11:132572791-132578511 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019931
 protein coding gene Chr11:123632774-123638663 (-)
PWK/PhJ MGP_PWKPhJ_G0018569
 protein coding gene Chr11:120155917-120162377 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018361
 protein coding gene Chr11:123390264-123397699 (-)
WSB/EiJ MGP_WSBEiJ_G0018855
 protein coding gene Chr11:123620366-123627754 (-)



Homology
more
  • Human Ortholog
    PDE6G, phosphodiesterase 6G
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE6G, phosphodiesterase 6G
  • Synonyms
    PDEG, RP57
  • Links
    NCBI Gene ID: 5148
    neXtProt AC: NX_P18545
    UniProt: P18545

  • Chr Location
    17q25.3; chr17:81650459-81663127 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pde6g mouse models; 1 with human PDE6G associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have poorly developed photoreceptors that degenerate with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    833
  • Tissues
    108
  • cDNA Data
    38
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18588 NCBI Gene Model | MGI Sequence Detail 5894 C57BL/6J ±  kb
    transcript NM_012065 RefSeq | MGI Sequence Detail 919 ZRU/MplStud  
    polypeptide P09174 UniProt | EBI | MGI Sequence Detail 87 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000012482 retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
      (term hierarchy)
    • EC
      3.1.4.35
    • InterPro Domains
      IPR006952 Retinal cGMP phosphodiesterase, gamma subunit
      IPR037030 Retinal cGMP phosphodiesterase, gamma subunit superfamily
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 39
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13210
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 7
      Phenotypes 28
    • Earliest
      J:32329 Tuteja N, et al., Gamma-subunit of mouse retinal cyclic-GMP phosphodiesterase: cDNA and corresponding amino acid sequence. FEBS Lett. 1988 May 9;232(1):182-6
    • Latest
      J:344348 Matalkah F, et al., The Musashi proteins direct post-transcriptional control of protein expression and alternate exon splicing in vertebrate photoreceptors. Commun Biol. 2022 Sep 24;5(1):1011
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory