Npr3 MGI Mouse Gene Detail - MGI:97373 - natriuretic peptide receptor 3

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Npr3 Gene Detail

Symbol

Npr3
Name

natriuretic peptide receptor 3
Synonyms

B430320C24Rik, lgj, longjohn, Nppc receptor, NPR-C

Feature Type

protein coding gene
IDs

MGI:97373
NCBI Gene: 18162
Alliance

gene page
Transcription Start Sites

5 TSS
Candidate for QTL

4 QTL

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Sequence Map

Chr15:11839982-11907287 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 5.83 cM
Mapping Data

7 experiments

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SNPs within 2kb

423 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_97373	protein coding gene	Chr15:11839982-11907373 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021732	protein coding gene	Chr15:9047703-9120446 (-)
A/J	MGP_AJ_G0021692	protein coding gene	Chr15:8773293-8841430 (-)
AKR/J	MGP_AKRJ_G0021670	protein coding gene	Chr15:8998651-9066427 (-)
BALB/cJ	MGP_BALBcJ_G0021699	protein coding gene	Chr15:8670534-8738726 (-)
C3H/HeJ	MGP_C3HHeJ_G0021475	protein coding gene	Chr15:8951126-9022707 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022138	protein coding gene	Chr15:9378210-9450229 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019675	protein coding gene	Chr15:8231164-8298465 (-)
CAST/EiJ	MGP_CASTEiJ_G0020991	protein coding gene	Chr15:9035163-9112566 (-)
CBA/J	MGP_CBAJ_G0021444	protein coding gene	Chr15:9651282-9733179 (-)
DBA/2J	MGP_DBA2J_G0021568	protein coding gene	Chr15:8629374-8695633 (-)
FVB/NJ	MGP_FVBNJ_G0021546	protein coding gene	Chr15:8482263-8551665 (-)
LP/J	MGP_LPJ_G0021636	protein coding gene	Chr15:8980724-9052732 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021571	protein coding gene	Chr15:9887245-9975270 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022161	protein coding gene	Chr15:8985262-9063034 (-)
PWK/PhJ	MGP_PWKPhJ_G0020734	protein coding gene	Chr15:8786064-8883781 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020572	protein coding gene	Chr15:8939143-9013154 (-)
WSB/EiJ	MGP_WSBEiJ_G0021047	protein coding gene	Chr15:8981031-9062229 (-)

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Human Ortholog

NPR3, natriuretic peptide receptor 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NPR3, natriuretic peptide receptor 3
Synonyms

ANP-C, ANPRC, ANPR-C, BOMOS, C5orf23, GUCY2B, NPRC, NPR-C
Links

HGNC:7945

NCBI Gene ID: 4883

neXtProt AC: NX_P17342

UniProt: P17342
Chr Location

5p13.3; chr5:32689070-32791724 (+) GRCh38

MGI Vertebrate Homology

Npr3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NPR3
Gene Tree

Npr3

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Diseases

1 with Npr3 mouse models; 1 with human NPR3 associations

Human Disease

Mouse Models

Mouse gene associated with disease

IDs

View 1 model

Human gene associated with disease

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

81 phenotypes from 10 alleles in 11 genetic backgrounds
5 images
44 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (ENU)

4
Endonuclease-mediated

8
Spontaneous

4
Targeted

9
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous inactivation of this gene leads to partial postnatal lethality, altered blood homeostasis, polyuria, hypovolemia, hypotension, increased bone turnover, skeletal deformities and altered adipose morphology. Spontaneous and ENU-induced mutations cause a skeletal-overgrowth phenotype.

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All GO Annotations

35
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1154
Tissues

182
cDNA Data

24
Literature Summary

26

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase npr3

ZFIN npr3

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All Sequences

76
RefSeq

17
UniProt

4
CCDS

CCDS27386.1, CCDS88735.1, CCDS88736.1

Ensembl

ENSMUSG00000022206 (Evidence)
NCBI Gene

18162

Representative Sequences				Length	Strain/Species	Flank
	genomic	18162	NCBI Gene Model \| MGI Sequence Detail	67306	C57BL/6J	± kb
	transcript	NM_008728	RefSeq \| MGI Sequence Detail	7359	ZRU/MplStud
	polypeptide	P70180	UniProt \| EBI \| MGI Sequence Detail	536	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011379 atrial natriuretic peptide receptor 3

(term hierarchy)
InterPro Domains

IPR001170 Adenylyl cyclase class-4/guanylyl cyclase

IPR028082 Periplasmic binding protein-like I

IPR001828 Receptor, ligand binding region

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All nucleic 36

Genomic 2

cDNA 25

Primer pair 5

Other 4

Microarray probesets 9

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MGD-MRK-12927, MGI:1330807, MGI:1330847, MGI:2146299, MGI:2442945

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Summaries

All 108

Developmental Gene Expression 26

Diseases 1

Gene Ontology 9

Phenotypes 44
Earliest

J:34286 Levin ER, et al., Natriuretic peptides inhibit rat astroglial proliferation: mediation by C receptor. Am J Physiol. 1991 Aug;261(2 Pt 2):R453-7
Latest

J:341863 Cheng C, et al., NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice. Signal Transduct Target Ther. 2023 Aug 9;8(1):290

TSS for Npr3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133756	Chr15:11907270-11907313 (-)	-5 bp
Tssr133755	Chr15:11906270-11906288 (-)	1,008 bp
Tssr133754	Chr15:11906242-11906268 (-)	1,032 bp
Tssr133753	Chr15:11906184-11906201 (-)	1,094 bp
Tssr133752	Chr15:11905695-11905709 (-)	1,585 bp

Npr3 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Bw11	Chr15, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.
Bwtq6	Chr15, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.
Dbsty4	Chr15, 41.96 cM	Chr15:87349271-87349416	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.
Mobq4	Chr15, 1.84 cM	Chr15:3489694-3489829	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.

*cM position of peak correlated region/marker

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