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Nppb Gene Detail
Summary
  • Symbol
    Nppb
  • Name
    natriuretic peptide type B
  • Synonyms
    BNP
  • Feature Type
    protein coding gene
  • IDs
    MGI:97368
    NCBI Gene: 18158
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:148070264-148071662 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 78.57 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    56 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97368
 protein coding gene Chr4:148070245-148071662 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029112
 protein coding gene Chr4:151674522-151675939 (+)
A/J MGP_AJ_G0029077
 protein coding gene Chr4:145402771-145404188 (+)
AKR/J MGP_AKRJ_G0029025
 protein coding gene Chr4:149359759-149361176 (+)
BALB/cJ MGP_BALBcJ_G0029093
 protein coding gene Chr4:145915857-145917274 (+)
C3H/HeJ MGP_C3HHeJ_G0028814
 protein coding gene Chr4:149914988-149916405 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029542
 protein coding gene Chr4:157193576-157194993 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026788
 protein coding gene Chr4:137826630-137828076 (+)
CAST/EiJ MGP_CASTEiJ_G0028227
 protein coding gene Chr4:147103974-147105385 (+)
CBA/J MGP_CBAJ_G0028776
 protein coding gene Chr4:161712867-161714284 (+)
DBA/2J MGP_DBA2J_G0028924
 protein coding gene Chr4:145507735-145509152 (+)
FVB/NJ MGP_FVBNJ_G0028889
 protein coding gene Chr4:144592150-144593567 (+)
LP/J MGP_LPJ_G0029015
 protein coding gene Chr4:151617115-151618532 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028916
 protein coding gene Chr4:165075373-165076790 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029574
 protein coding gene Chr4:149840228-149841645 (+)
PWK/PhJ MGP_PWKPhJ_G0027947
 protein coding gene Chr4:141489396-141490985 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027781
 protein coding gene Chr4:144102032-144103439 (+)
WSB/EiJ MGP_WSBEiJ_G0028307
 protein coding gene Chr4:149978735-149980152 (+)



Homology
more
  • Human Ortholog
    NPPB, natriuretic peptide B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPPB, natriuretic peptide B
  • Synonyms
    BNP, Iso-ANP
  • Links
    NCBI Gene ID: 4879
    neXtProt AC: NX_P16860
    UniProt: P16860

  • Chr Location
    1p36.22; chr1:11857464-11858945 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human NPPB associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation develop multifocal fibrotic ventricular lesions which become larger and more numerous under conditions of ventricular pressure overload.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    786
  • Tissues
    17
  • cDNA Data
    18
  • Literature Summary
    100
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18158 NCBI Gene Model | MGI Sequence Detail 1399 C57BL/6J ±  kb
    transcript NM_008726 RefSeq | MGI Sequence Detail 669 ZRU/MplStud  
    polypeptide P40753 UniProt | EBI | MGI Sequence Detail 121 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 12
      cDNA 18
      Primer pair 12
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12922, MGI:2140128
    References
    more
    • Summaries
      All 169
      Developmental Gene Expression 100
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:34720 Seidman CE, et al., The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone. Science. 1984 Jul 20;225(4659):324-6
    • Latest
      J:345821 Allwood MA, et al., Novel roles of cardiac-derived erythropoietin in cardiac development and function. J Mol Cell Cardiol. 2024 Mar;188:90-104
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory