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Tpsb2 Gene Detail
Summary
  • Symbol
    Tpsb2
  • Name
    tryptase beta 2
  • Synonyms
    Mcp6, Mcp-6, Mcpt6, MMCP-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:96942
    NCBI Gene: 17229
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25585282-25587070 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.53 cM, cytoband A3.3
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96942
 protein coding gene Chr17:25585170-25588079 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023353
 protein coding gene Chr17:24430241-24431785 (+)
A/J MGP_AJ_G0023312
 protein coding gene Chr17:23738129-23739673 (+)
AKR/J MGP_AKRJ_G0023278
 protein coding gene Chr17:23837526-23839070 (+)
BALB/cJ MGP_BALBcJ_G0023317
 protein coding gene Chr17:23945142-23946686 (+)
C3H/HeJ MGP_C3HHeJ_G0023077
 protein coding gene Chr17:24211223-24212767 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023759
 protein coding gene Chr17:25491360-25492904 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021235
 protein coding gene Chr17:21199407-21200936 (+)
CAST/EiJ MGP_CASTEiJ_G0022579
 protein coding gene Chr17:24079915-24081462 (+)
CBA/J MGP_CBAJ_G0023052
 protein coding gene Chr17:26356661-26358205 (+)
DBA/2J MGP_DBA2J_G0023182
 protein coding gene Chr17:23334785-23336329 (+)
FVB/NJ MGP_FVBNJ_G0023152
 protein coding gene Chr17:23052499-23054043 (+)
LP/J MGP_LPJ_G0023259
 protein coding gene Chr17:24720108-24721652 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023171
 protein coding gene Chr17:26011426-26012970 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023799
 protein coding gene Chr17:24124125-24125669 (+)
PWK/PhJ MGP_PWKPhJ_G0022328
 protein coding gene Chr17:22089098-22090642 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022146
 protein coding gene Chr17:22208827-22210370 (+)
WSB/EiJ MGP_WSBEiJ_G0022642
 protein coding gene Chr17:24190016-24191560 (+)



Homology
more
  • Human Ortholog
    TPSAB1, tryptase alpha/beta 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TPSAB1, tryptase alpha/beta 1
  • Synonyms
    TPS1, TPS2, TPSB1, TPSB2, Tryptase-2
  • Links
    NCBI Gene ID: 7177
    neXtProt AC: NX_P20231, NX_Q15661
    UniProt: Q15661

  • Chr Location
    16p13.3; chr16:1239266-1242554 (+)  GRCh38
  • Human Ortholog
    TPSB2, tryptase beta 2
  • Synonyms
    TPS2, tryptaseB, tryptaseC
  • Links
    NCBI Gene ID: 64499
    neXtProt AC: NX_P20231
    UniProt: P20231

  • Chr Location
    16p13.3; chr16:1227272-1232757 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show reduced recruitment of eosinophils to sites of T. spiralis larvae and decreased elimination of larvae in chronically infected skeletal muscle. Mice homozygous for a knock-in allele show a reduced ability to clear K. pneumoniae from their peritoneal cavity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    792
  • Tissues
    52
  • cDNA Data
    24
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17229 NCBI Gene Model | MGI Sequence Detail 1789 C57BL/6J ±  kb
    transcript NM_010781 RefSeq | MGI Sequence Detail 1088 Not Specified  
    polypeptide P21845 UniProt | EBI | MGI Sequence Detail 276 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 2
      cDNA 24
      Primer pair 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12148, MGD-MRK-12156, MGI:2147011
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 16
    • Earliest
      J:17707 Reynolds DS, et al., Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases. Proc Natl Acad Sci U S A. 1990 Apr;87(8):3230-4
    • Latest
      J:333559 Rupani DN, et al., Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling. Development. 2023 Jan 15;150(2):dev201097
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory