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Lcn2 Gene Detail
Summary
  • Symbol
    Lcn2
  • Name
    lipocalin 2
  • Synonyms
    24p3, neu-related lipocalin, NGAL, NRL
  • Feature Type
    protein coding gene
  • IDs
    MGI:96757
    NCBI Gene: 16819
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:32274649-32277751 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.09 cM, cytoband A3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96757
 protein coding gene Chr2:32274645-32278264 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025605
 protein coding gene Chr2:30834645-30838264 (-)
A/J MGP_AJ_G0025582
 protein coding gene Chr2:29528910-29532536 (-)
AKR/J MGP_AKRJ_G0025552
 protein coding gene Chr2:30584916-30588535 (-)
BALB/cJ MGP_BALBcJ_G0025579
 protein coding gene Chr2:29654709-29658328 (-)
C3H/HeJ MGP_C3HHeJ_G0025339
 protein coding gene Chr2:30476303-30479922 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026023
 protein coding gene Chr2:31776703-31780907 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023432
 protein coding gene Chr2:28255098-28258824 (-)
CAST/EiJ MGP_CASTEiJ_G0024801
 protein coding gene Chr2:30412247-30415875 (-)
CBA/J MGP_CBAJ_G0025317
 protein coding gene Chr2:32973173-32976792 (-)
DBA/2J MGP_DBA2J_G0025450
 protein coding gene Chr2:29297847-29301466 (-)
FVB/NJ MGP_FVBNJ_G0025412
 protein coding gene Chr2:29174219-29177838 (-)
LP/J MGP_LPJ_G0025536
 protein coding gene Chr2:30712616-30716235 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025443
 protein coding gene Chr2:32633991-32637617 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026081
 protein coding gene Chr2:30466228-30470913 (-)
PWK/PhJ MGP_PWKPhJ_G0024549
 protein coding gene Chr2:29201079-29204811 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024349
 protein coding gene Chr2:30623027-30628233 (-)
WSB/EiJ MGP_WSBEiJ_G0024870
 protein coding gene Chr2:30639062-30642681 (-)



Homology
more
  • Human Ortholog
    LCN2, lipocalin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LCN2, lipocalin 2
  • Synonyms
    24p3, MSFI, NGAL, p25
  • Links
    NCBI Gene ID: 3934
    neXtProt AC: NX_P80188
    UniProt: P80188

  • Chr Location
    9q34.11; chr9:128149071-128153453 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LCN2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    53 phenotypes from 4 alleles in 7 genetic backgrounds
    172 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants are more susceptible to infection with bacteria that utilize enterochelin-type siderophores to acquire iron and impaired thermogenesis. Mice homozygous for another knock-out allele exhibit apoptotic defects in hematopoietic cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    797
  • Tissues
    32
  • cDNA Data
    545
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16819 NCBI Gene Model | MGI Sequence Detail 3103 C57BL/6J ±  kb
    transcript NM_008491 RefSeq | MGI Sequence Detail 853 Swiss  
    polypeptide P11672 UniProt | EBI | MGI Sequence Detail 200 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 550
      cDNA 545
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11759, MGI:2139327
    References
    more
    • Summaries
      All 269
      Developmental Gene Expression 19
      Gene Ontology 13
      Phenotypes 172
    • Earliest
      J:20468 Hraba-Renevey S, et al., SV40-induced expression of mouse gene 24p3 involves a post-transcriptional mechanism. Oncogene. 1989 May;4(5):601-8
    • Latest
      J:342373 Saenz-Pipaon G, et al., Role of LCN2 in a murine model of hindlimb ischemia and in peripheral artery disease patients, and its potential regulation by miR-138-5P. Atherosclerosis. 2023 Oct 11;385:117343
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory