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Jun Gene Detail
Summary
  • Symbol
    Jun
  • Name
    jun proto-oncogene
  • Synonyms
    c-jun, Junc
  • Feature Type
    protein coding gene
  • IDs
    MGI:96646
    NCBI Gene: 16476
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:94937273-94940459 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 43.34 cM, cytoband C5-C7
  • Mapping Data
    34 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96646
 protein coding gene Chr4:94937271-94940459 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028456
 protein coding gene Chr4:95099975-95103163 (-)
A/J MGP_AJ_G0028419
 protein coding gene Chr4:91776805-91779992 (-)
AKR/J MGP_AKRJ_G0028366
 protein coding gene Chr4:93973271-93976459 (-)
BALB/cJ MGP_BALBcJ_G0028437
 protein coding gene Chr4:92018047-92021234 (-)
C3H/HeJ MGP_C3HHeJ_G0028150
 protein coding gene Chr4:94793355-94796542 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028876
 protein coding gene Chr4:98755429-98758617 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026170
 protein coding gene Chr4:87271563-87274742 (-)
CAST/EiJ MGP_CASTEiJ_G0027590
 protein coding gene Chr4:92655062-92658255 (-)
CBA/J MGP_CBAJ_G0028119
 protein coding gene Chr4:101754990-101758177 (-)
DBA/2J MGP_DBA2J_G0028269
 protein coding gene Chr4:91567710-91570896 (-)
FVB/NJ MGP_FVBNJ_G0028236
 protein coding gene Chr4:90431058-90434246 (-)
LP/J MGP_LPJ_G0028369
 protein coding gene Chr4:95424165-95427353 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028264
 protein coding gene Chr4:107524146-107527333 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028914
 protein coding gene Chr4:94267008-94270196 (-)
PWK/PhJ MGP_PWKPhJ_G0027315
 protein coding gene Chr4:89708709-89711896 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027136
 protein coding gene Chr4:91663110-91666292 (-)
WSB/EiJ MGP_WSBEiJ_G0027668
 protein coding gene Chr4:94403723-94406911 (-)



Homology
more
  • Human Ortholog
    JUN, Jun proto-oncogene, AP-1 transcription factor subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    JUN, Jun proto-oncogene, AP-1 transcription factor subunit
  • Synonyms
    AP1, AP-1, c-Jun, cJUN, p39
  • Links
    NCBI Gene ID: 3725
    neXtProt AC: NX_P05412
    UniProt: P05412

  • Chr Location
    1p32.1; chr1:58776845-58784048 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Jun mouse models; 1 with human JUN associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    96 phenotypes from 10 alleles in 18 genetic backgrounds
    30 phenotypes from multigenic genotypes
    4 images
    103 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null homozygotes die at midgestation with impaired hepatogenesis, altered fetal liver erythropoiesis and edema. A mutant replacing two serines by alanines is viable, fertile, small-sized and resistant to kainate-induced seizures and neuronal apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    130
  • GO References
    37
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1225
  • Tissues
    279
  • cDNA Data
    144
  • Literature Summary
    158
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16476 NCBI Gene Model | MGI Sequence Detail 3187 C57BL/6J ±  kb
    transcript NM_010591 RefSeq | MGI Sequence Detail 3187 ZRU/MplStud  
    polypeptide P05627 UniProt | EBI | MGI Sequence Detail 334 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 168
      Genomic 4
      cDNA 150
      Primer pair 12
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11538, MGD-MRK-11540
    References
    more
    • Summaries
      All 532
      Developmental Gene Expression 158
      Diseases 2
      Gene Ontology 37
      Phenotypes 103
    • Earliest
      J:9056 Ryder K, et al., A gene activated by growth factors is related to the oncogene v-jun. Proc Natl Acad Sci U S A. 1988 Mar;85(5):1487-91
    • Latest
      J:343798 Cheng T, et al., Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease. Development. 2023 Dec 15;150(24)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/09/2024
    MGI 6.23     		The Jackson Laboratory