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Igfbp1 Gene Detail
Summary
  • Symbol
    Igfbp1
  • Name
    insulin-like growth factor binding protein 1
  • Synonyms
    IGFBP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96436
    NCBI Gene: 16006
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:7147787-7152546 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 4.75 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96436
 protein coding gene Chr11:7147782-7152546 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018033
 protein coding gene Chr11:4398227-4402943 (+)
A/J MGP_AJ_G0018006
 protein coding gene Chr11:4177918-4182576 (+)
AKR/J MGP_AKRJ_G0017970
 protein coding gene Chr11:4373811-4378469 (+)
BALB/cJ MGP_BALBcJ_G0017974
 protein coding gene Chr11:4177078-4181794 (+)
C3H/HeJ MGP_C3HHeJ_G0017787
 protein coding gene Chr11:4277796-4282597 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018426
 protein coding gene Chr11:4483212-4487928 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016084
 protein coding gene Chr11:4048437-4052980 (+)
CAST/EiJ MGP_CASTEiJ_G0017349
 protein coding gene Chr11:4270076-4274857 (+)
CBA/J MGP_CBAJ_G0017762
 protein coding gene Chr11:4978094-4982810 (+)
DBA/2J MGP_DBA2J_G0017872
 protein coding gene Chr11:4094458-4099174 (+)
FVB/NJ MGP_FVBNJ_G0017864
 protein coding gene Chr11:4135684-4140485 (+)
LP/J MGP_LPJ_G0017943
 protein coding gene Chr11:4451909-4456625 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017890
 protein coding gene Chr11:4512399-4517057 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018466
 protein coding gene Chr11:4426304-4431020 (+)
PWK/PhJ MGP_PWKPhJ_G0017129
 protein coding gene Chr11:4136057-4140838 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016926
 protein coding gene Chr11:4349770-4354451 (+)
WSB/EiJ MGP_WSBEiJ_G0017403
 protein coding gene Chr11:4232808-4237572 (+)



Homology
more
  • Human Ortholog
    IGFBP1, insulin like growth factor binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGFBP1, insulin like growth factor binding protein 1
  • Synonyms
    AFBP, hIGFBP-1, IBP1, IGF-BP25, PP12
  • Links
    NCBI Gene ID: 3484
    neXtProt AC: NX_P08833
    UniProt: P08833

  • Chr Location
    7p12.3; chr7:45888360-45893660 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IGFBP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene desplay a grossly normal phenotype but are more susceptible to liver injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    42
  • cDNA Data
    45
  • Literature Summary
    39
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16006 NCBI Gene Model | MGI Sequence Detail 4760 C57BL/6J ±  kb
    transcript NM_008341 RefSeq | MGI Sequence Detail 1522 ZRU/MplStud  
    polypeptide P47876 UniProt | EBI | MGI Sequence Detail 272 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000008947 insulin-like growth factor-binding protein 1
      (term hierarchy)
    • InterPro Domains
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR022322 Insulin-like growth factor-binding protein 1
      IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
      IPR000867 Insulin-like growth factor-binding protein, IGFBP
      IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
      IPR000716 Thyroglobulin type-1
      IPR036857 Thyroglobulin type-1 superfamily
    Molecular
    Reagents
    less
    • All nucleic 102
      Genomic 48
      cDNA 46
      Primer pair 8

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11233
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 39
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:34028 O'Brien TP, et al., Expression of cyr61, a growth factor-inducible immediate-early gene. Mol Cell Biol. 1990 Jul;10(7):3569-77
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory